Primary cardiac tumors: experience at the University of Minnesota.
Primary cardiac tumors: experience at the University of Minnesota.
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DOI：
10.1055/s-2007-1014064
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发表时间：
1990-08-01
期刊：
影响因子：
--
通讯作者：
Ward, H B
中科院分区：
文献类型：
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作者：
Molina, J E;Edwards, J E;Ward, H B
对1959年至1989年期间在明尼苏达大学发现的或在明尼苏达大学附属心血管疾病登记处登记的所有原发性心脏肿瘤的回顾。在124例原发性心脏肿瘤中，良性肿瘤103例（83%），恶性肿瘤21例（17%）。心房粘液瘤（51例）占所有肿瘤的42%，占良性肿瘤的50%。其余51例良性肿瘤按发生率顺序为：横纹肌瘤14例（13%）、乳头状瘤12例（11%）、纤维瘤9例（9%）、错构瘤（4%）、畸胎瘤（2%）、脂肪瘤（2%）、间皮瘤（2%）、纤维瘤、血管瘤、血管球瘤和其他少数肿瘤。21例恶性肿瘤均为肉瘤，按发生频率顺序为：横纹肌肉瘤6例（29%），血管肉瘤4例（19%），粘液瘤3例（14%），纤维肉瘤2例（10%），平滑肌肉瘤、网状细胞肉瘤和脂肪肉瘤各1例。3例梭形细胞肉瘤（14%）起源于大血管：1例在肺动脉，2例在主动脉。切除的良性肿瘤预后良好，随访15年无复发并发症。不能切除的肿瘤主要包括新生儿的横纹肌瘤和累及大部分心脏的海绵状血管瘤，预后差。心脏恶性肿瘤的预后非常差，即使在诊断后立即手术。这些患者的平均生存时间为5个月后切除，即使随后化疗和/或放疗; 26%的肿瘤已经转移，在手术时。恶性肿瘤广泛切除效果不佳。
A review of all primary cardiac tumors seen at the University of Minnesota or entered in the Registry of Cardiovascular Disease, affiliated with the University of Minnesota, between 1959 and 1989. Of a total of 124 primary cardiac tumors, 103 (83%) were benign and 21 (17%) were malignant. Atrial myxomas (51 cases) accounted for 42% of all tumors and 50% of benign neoplasias. The remaining 51 benign tumors were, in order of frequency: rhabdomyomas, 14 (13%), papillomas, 12 (11%), fibromas, 9 (9%), hamartomas, (4%), teratomas (2%), lipomas (2%), mesotheliomas (2%), fibroelastomas, hemangiomas, glomangiomas, and a few others. The 21 malignant tumors, all sarcomas, were, in order of frequency: rhabdomyosarcomas, 6 (29%), angiosarcomas, 4 (19%), myxosarcomas, 3 (14%), fibrosarcomas, 2 (10%), and one each leiomyosarcoma, reticulum cell sarcoma, and liposarcoma. There were 3 cases of spindle cell sarcoma (14%) originating in the great vessels: 1 in the pulmonary artery and 2 in the aorta. The prognosis of the resected benign tumors was good, with no complications of recurrences for up to 15 years of follow-up. Tumors that could not be excised included mostly rhabdomyomas, in newborns, and cavernous hemangiomas involving most of the heart, with poor prognosis. Malignant tumors of the heart had a very poor prognosis, even when operated on promptly after diagnosis. The mean survival time of these patients was 5 months after resection, even when followed with chemotherapy and/or radiation; 26% of the tumors had already metastasized at the time of operation. Extensive resections in malignant tumors did not render satisfactory results.