Effect of Variation in Dietary NaCl Intake on Total and Fractional Renal Blood Flow in the Normal and Mercury‐Intoxicated Rat
Effect of Variation in Dietary NaCl Intake on Total and Fractional Renal Blood Flow in the Normal and Mercury‐Intoxicated Rat
复制标题
膳食氯化钠摄入量变化对正常和汞中毒大鼠肾血流量总量和分数的影响
DOI：
10.1161/01.res.39.4.506
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发表时间：
1976
影响因子：
20.1
通讯作者：
I. Leusen
中科院分区：
文献类型：
--
作者：
N. Lameire;S. Ringoir;I. Leusen
本文研究了不同慢性（3-4周）食盐摄入量对正常和汞中毒大鼠肾内血流动力学的影响。用放射性微球法测定心输出量（CO）、肾血流量（RBF）、皮质外区（OC）和皮质内区（IC）灌注率。计算皮质血流的分布作为分布指数（DI），其反映了OC/IC的比值。将大鼠置于高盐饮食（组I）、中等盐饮食（组II）或低盐饮食（组III）。对每组进行对照大鼠（亚组A）和汞中毒大鼠（亚组B）研究。不同盐摄入量对DI没有影响。IA组DI为2.35 ± 0.14，IIA组为2.40 ± 0.16，IIIA组为2.38 ± 0.09（P > 0.05）。注汞后RBF由5.32 ± 0.36 ml/g min ~（-1）（IIA）变为3.31 ± 0.20 ml/g min ~（-1）（IIB），由4.32 ± 0.11 ml/g min ~（-1）（IIIA）变为1.98 ± 0.10 ml/g min ~（-1）（IIIB）（P < 0.01）。IIB组DI降至1.53 ± 0.06（P < 0.05），IIIB组降至1.16 ± 0.10（P < 0.01）。在IIB和IIIB中均观察到血尿素显著升高（IIB = 97 ± 9 mg/100 ml和IIIB = 182 ± 25 mg/100 ml）。在IB组中，尽管组织学肾脏病变相似，但未观察到对RBF、OC、IC或DI的影响（对于所有值，P > 0.05）。IB组大鼠也具有正常的血尿素水平（31 ± 6 mg/100 ml; p> 0.05）。我们的结论是：（1）饮食盐摄入量的变化似乎对皮质内血流分布没有可检测的影响;此外（2）汞诱导的急性肾功能衰竭（ARF）的血流动力学特征是全肾和优先外皮质缺血，慢性盐负荷可防止ARF，同时保持正常的肾灌注。
We studied the effect of different chronic (3–4 weeks) dietary salt intakes on intrarenal hemodynamics of normal and mercury-intoxicated rats. Cardiac output (CO), total renal blood flow (RBF), and the zonal pcrfusion rate in the outer cortex (OC) and inner cortex (IC) were measured by the radioactive microsphere method. The distribution of cortical blood flow was calculated as the distribution index (DI), which reflects the ratio OC/IC. Rats were placed on a high salt diet (group I), intermediate salt diet (group II), or low salt diet (group III). For each group control rats (subgroup A) and mercury-intoxicated rats (subgroup B) were studied. No effect of the different salt intakes on the DI could be detected. The DI in group IA was 2.35 ± 0.14; in IIA, 2.40 ± 0.16; and in IIIA, 2.38 ± 0.09 (P > 0.05). After mercury injection RBF changed from 5.32 ± 0.36 ml/g min1 (IIA) to 3.31 ± 0.20 ml/g min1 (IIB), and from 4.32 & plusmn; 0.11 ml/g min-1 (IIIA) to 1.98 ± 0.10 ml/g min-1 (IIIB) (P < 0.01). The DI was lowered to 1.53 ± 0.06 (IIB) (P < 0.05) and to 1.16 ± 0.10 (IIIB) (P < 0.01). In both IIB and IIIB a marked elevation of the blood urea was noted (IIB = 97 ± 9 mg/100 ml and IIIB = 182 ± 25 mg/100 ml). In group IB no effect on RBF, OC, IC, or DI could be observed (for all values, P > 0.05) despite similar histological renal lesions. Croup IB rats also had normal blood urea levels (31 ± 6 mg/100 ml;/' > 0.05). We conclude (1) that variations in dietary salt intake appear to have no detectable effect on the intracortical blood flow distribution; and furthermore (2) that the mercury-induced acute renal failure (ARF) is characterized hemo-dynamically by a total renal and preferential outer cortical ischemia and that chronic salt loading prevents the ARF while preserving normal renal pcrfusion.