Antimicrobial susceptibility of Staphylococcus aureus isolated from bovine mastitis in Europe and the United States
Antimicrobial susceptibility of Staphylococcus aureus isolated from bovine mastitis in Europe and the United States
复制标题
DOI：
10.3168/jds.s0022-0302(00)74949-6
复制
发表时间：
2000-04-01
影响因子：
3.5
通讯作者：
Aerestrup, FM
中科院分区：
文献类型：
--
作者：
De Oliveira, AP;Watts, JL;Aerestrup, FM
测定了从11个国家牛乳腺炎病例中分离的811株金黄色葡萄球菌的最低抑菌浓度。分离株的国家和数量包括丹麦（105）、英格兰（92）、芬兰（95）、德国（103）、冰岛（22）、爱尔兰（42）、挪威（101）、瑞典（123）、瑞士（69）、美国（53）和津巴布韦（6）。检测的抗菌药物为青霉素、氨苄西林、苯唑西林、头孢噻吩、头孢噻呋、阿莫西林+克拉维霉素、青霉素+新生霉素、恩诺沙星、普马沙星、红霉素、克林霉素、林可霉素、吡利霉素、新霉素、林可霉素+新霉素和磺胺二甲嘧啶。这些抗菌剂对所有菌株的MIC 90分别为0.5、1.0、1.0、0.5、1.0、小于或等于0.06、0.125、0.125、小于或等于0.0078、0.5、1.0、16.0、1.0、2.0、0.5和4.0 μ g/ml。总体而言，大多数受试化合物的MIC 90在国家之间仅存在微小差异。在测试的菌株中，35.6%在初始测试时对β-内酰胺酶产生呈阳性，另外21.3%在青霉素诱导后呈阳性。总之，无论哪个国家，所有检测的抗菌药物的总体耐药性水平普遍较低。鉴于不同国家抗菌药物使用的差异，乳腺炎控制计划的广泛采用，以防止感染限制了S。金黄色葡萄球菌感染的动物抗菌药物。
Minimum inhibitory concentrations were determined for 811 strains of Staphylococcus aureus isolated from cases of bovine mastitis in 11 countries. The countries and number of isolates included Denmark (105), England (92), Finland (95), Germany (103), Iceland (22), Ireland (42), Norway (101), Sweden (123), Switzerland (69), United States (53), and Zimbabwe (6). The antimicrobial agents tested were penicillin, ampicillin, oxacillin, cephalothin, ceftiofur, amoxicillin + clavulanate, penicillin + novobiocin, enrofloxacin, premafloxacin, erythromycin, clindamycin, lincomycin, pirlimycin, neomycin, lincomycin + neomycin, and sulfamethazine. The MIC90 for these antimicrobial agents for all strains were 0.5, 1.0, 1.0, 0.5, 1.0, less than or equal to 0.06, 0.125, 0.125, less than or equal to 0.0078, 0.5, 1.0, 16.0, 1.0, 2.0, 0.5, and 4.0 mu g/ml, respectively. Overall, only small variations between countries were seen in the MIC90 for the majority of compounds tested. Of the strains tested, 35.6% were positive for beta-lactamase production on initial testing, with an additional 21.3% positive after induction by penicillin. In conclusion, the overall level of resistance was generally low for all antimicrobial agents tested regardless of country. Given the differences in antimicrobial use in various countries, the widespread adoption of mastitis control programs to prevent infections limits the exposure of S. aureus infected animals to antimicrobial drugs.