Inflammation in bone physiology and pathology.
Inflammation in bone physiology and pathology.
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DOI：
10.1097/bor.0000000000000449
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发表时间：
2018-01
影响因子：
5.1
通讯作者：
Adamopoulos IE
中科院分区：
文献类型：
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作者：
Adamopoulos IE
在整个成人生活中，骨骼通过维持组织稳态的持续合成代谢和分解代谢作用不断重塑。许多激素、细胞因子、生长因子和各种细胞与骨表面的接近性影响这一过程。骨微环境的炎性变化导致改变，导致过度骨丢失和骨形成。详细了解这些变化的生理和病理机制将使我们能够利用骨再生中的炎症信号。最近的报告表明，炎症信号能够刺激转录因子，调节成骨细胞从其前体分化。在这篇综述中，我们总结了目前对炎症在骨吸收和骨形成中的作用的理解，这些炎症引起不同的病理，并讨论了利用这些炎症信号来实现骨再生的巨大潜力。
Bone is constantly being remodeled throughout adult life through constant anabolic and catabolic actions that maintain tissue homeostasis. A number of hormones, cytokines growth factors and the proximity of various cells to bone surfaces influence this process. Inflammatory changes at the bone microenvironment result in alterations leading to both excessive bone loss and bone formation. Detailed understanding of the physiological and pathological mechanisms that dictate these changes will allow us to harness inflammatory signals in bone regeneration. Recent reports have suggested that inflammatory signals are able to stimulate transcription factors that regulate osteoblast differentiation from their precursors. In this review we summarized current understanding of the roles of inflammation in bone resorption and bone formation, which give rise to different pathologies and discuss the huge potential of harnessing these inflammatory signals to achieve bone regeneration.