HMG CoA reductase inhibitor fluvastatin arrests the development of implanted hepatocarcinoma in rats.
HMG CoA reductase inhibitor fluvastatin arrests the development of implanted hepatocarcinoma in rats.
复制标题
HMG CoA 还原酶抑制剂氟伐他汀可阻止大鼠体内植入性肝癌的发展。
作者：
G. Paragh;P. Kertai;P. Kovacs;G. Paragh;P. Fülöp;G. Fóris
背景
氟伐他汀 (Flu) 被广泛认为具有抗癌作用，尽管其体内癌症化学预防能力尚未研究。本研究在体内比较了流感的治疗和化学预防作用。
材料和方法
在FLF1杂交大鼠的左肾被膜下，将10(6)个肝癌细胞(He/De14)植入海绵盘上。将左肾和右肾之间的净重差异确定为肿瘤重量。流感按 0.5、2 和 20 mg/kg/天的剂量经口给药。
结果
肿瘤植入前21天的流感预处理对植入后不进行流感治疗的肿瘤发展没有影响。在肿瘤植入之前和之后添加 Flu 表现出比仅在肿瘤植入之后给予治疗的情况更强烈的抗癌效果。
结论
流感在 0.5-20 毫克/公斤/天的剂量下对大鼠肝癌生长具有治疗和预防作用，具体取决于给药类型。
BACKGROUND
Fluvastain (Flu) is widely accepted to have anticancer effect although its in vivo chemopreventive ability in cancer has not been studied. The therapeutic and chemopreventive effects of Flu were compared in vivo in the present study.
MATERIALS AND METHODS
Under the left renal capsule of FLF1 hybrid rats 10(6) hepatocarcinoma cells were implanted (He/De14) on sponge disc. The differences in net weight between the left and right kidneys were determined as tumor weights. Flu was administered per os in 0.5, 2 and 20 mg/kg/day doses.
RESULTS
The 21-day pretreatment before tumor implantation with Flu had no effect on tumor development in the absence of Flu treatment after the implantation. The addition of Flu before and after tumor implantation demonstrated a more intensive anticancer effect than in the case of treatment given only after tumor implantation.
CONCLUSION
Flu has in 0.5-20 mg/kg/day doses a therapeutic and also a preventive effect on hepatocarcinoma growth in rats depending on the type of administration.