High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma
High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma
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DOI：
10.1007/s13277-015-3748-9
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发表时间：
2015-12-01
期刊：
影响因子：
--
通讯作者：
Pang, Da
中科院分区：
文献类型：
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作者：
Cui, Yan;Niu, Ming;Pang, Da
Valosin-containing protein（VCP）是AAA-ATPase超家族成员之一。VCP的高表达与肿瘤的进展、预后和转移潜能之间的相关性已在各种肿瘤类型中得到证实。然而，VCP在乳腺癌中的临床影响尚未研究。本研究检测421例乳腺肿瘤及癌旁正常乳腺组织中VCP的表达，探讨VCP表达与乳腺癌临床病理特征的关系。VCP的表达与肿瘤的TNM分期、Ki-67标记及淋巴结转移密切相关。VCP在乳腺癌细胞胞浆中的表达明显高于正常乳腺上皮细胞（P < 0.001），与乳腺癌患者的生存率有关。总之，本研究表明VCP的胞浆表达与乳腺癌的不良预后显著相关，提示VCP可作为乳腺癌的预后生物标志物。
Valosin-containing protein (VCP) is one of the AAA-ATPase superfamily members. The correlation between elevated expression of VCP and progression, prognosis, and the metastatic potential has been identified in various tumor types. However, the clinical impact of VCP in breast carcinoma has not been investigated. In the current study, the expression of VCP in 421 breast tumors and adjacent normal breast tissues was examined to investigate the correlation between VCP expression and clinicopathological features in patients with breast carcinoma. We found that the expression of VCP correlated with the TNM stage, Ki67 labeling, and lymph node metastasis (LNM). The expression of VCP was increased significantly in the cytoplasm of cancer cells compared to normal mammary epithelial cells, which was associated with decreased overall survival rates of patients with breast carcinoma (P < 0.001). In conclusion, this study demonstrates significant correlation between the cytoplasmic expression of VCP and adverse prognosis in breast carcinoma, suggesting that VCP may serve as a prognostic biomarker in breast carcinoma.