The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord.
The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord.
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DOI：
10.7554/elife.65304
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发表时间：
2021-09-09
期刊：
影响因子：
7.7
通讯作者：
Cordero-Erausquin M
中科院分区：
文献类型：
--
作者：
Moreno-Lopez Y;Bichara C;Delbecq G;Isope P;Cordero-Erausquin M
通常认为皮质脊髓束（CST）的主要功能是将运动命令传递给延髓或脊髓运动神经元。然而，CST 也被证明可以通过初级传入去极化 (PAD) 调节脊髓入口点的感觉信号。通过电生理记录和交叉病毒策略依次研究离皮质途径的不同途径，我们在此证明小鼠的运动和感觉调节命令属于 CST 内的分离路径。感觉调节完全由 CST 通过位于背角深部的腰椎中间神经元群执行。相反，皮层通过上脊髓或脊髓上运动中心的中继传达运动命令。因此，在腰椎层面，CST 的主要作用是调节感觉输入，这是选择性调节感觉反馈的重要组成部分，用于确保良好协调和熟练的运动。
It is generally assumed that the main function of the corticospinal tract (CST) is to convey motor commands to bulbar or spinal motoneurons. Yet the CST has also been shown to modulate sensory signals at their entry point in the spinal cord through primary afferent depolarization (PAD). By sequentially investigating different routes of corticofugal pathways through electrophysiological recordings and an intersectional viral strategy, we here demonstrate that motor and sensory modulation commands in mice belong to segregated paths within the CST. Sensory modulation is executed exclusively by the CST via a population of lumbar interneurons located in the deep dorsal horn. In contrast, the cortex conveys the motor command via a relay in the upper spinal cord or supraspinal motor centers. At lumbar level, the main role of the CST is thus the modulation of sensory inputs, which is an essential component of the selective tuning of sensory feedback used to ensure well-coordinated and skilled movement.