Effect of NBS1 gene polymorphism on the risk of cervix carcinoma in a northern Indian population
Effect of NBS1 gene polymorphism on the risk of cervix carcinoma in a northern Indian population
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DOI：
10.1177/172460080802300301
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发表时间：
2008-07-01
影响因子：
2
通讯作者：
Huria, A.
中科院分区：
文献类型：
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作者：
Sobti, R. C.;Shekari, M.;Huria, A.
宫颈癌是影响女性最常见的肿瘤疾病之一，全球发病率近 50 万例。吸烟史和使用口服避孕药已被证实是宫颈癌的危险因素。遗传易感性和免疫反应，特别是细胞免疫反应受损，很可能与宫颈癌的发生有关。 NBS1 是参与双链断裂识别和修复的关键蛋白之一，如果不修复，双链断裂可能会导致基因组不稳定和癌症。因此，本研究的目的是调查印度北部人群的 NBS1 Glu185Gln 基因多态性和患宫颈癌的风险。我们发现，具有特定 NBS1 基因型（Glu/Gln、Gln/Gln 或 Glu/Gln + Gln/Gln）的被动吸烟者患宫颈癌的风险增加（分别为 OR 5.21，p=0.000001；OR 4.60，p=0.001；OR 5.10，p=0.0000009）。具有 Glu/Gln 基因型的口服避孕药使用者的风险增加了 2.4 倍。我们得出的结论是，被动吸烟者和使用某些 NBS1 基因型口服避孕药的人患宫颈癌的风险会增加。 （《国际生物标记杂志》2008 年；23：133-9）
Cervical cancer is one of the most common neoplastic diseases affecting women, with a worldwide incidence of almost half a million cases. A history of smoking and use of oral contraceptives have been confirmed to be risk factors for cervical cancer. Genetic susceptibility and immune response, especially impaired cellular immune response, may well be related to the development of cervical cancer. NBS1 is one of the key proteins participating in the recognition and repair of double-strand breaks that may lead to genomic instability and cancer if unrepaired. The objective of the present study was therefore to investigate NBS1 Glu185Gln gene polymorphisms and the risk of cervix cancer in a northern Indian population. We found that passive smokers having particular NBS1 genotypes (Glu/Gln, Gln/Gln or Glu/Gln + Gln/Gln) have an increased risk of developing cervix cancer (OR 5.21, p=0.000001; OR 4.60, p=0.001; OR 5.10, p=0.0000009, respectively). The risk was increased 2.4-fold in oral contraceptive users with a Glu/Gln genotype. We conclude that the risk of cervical cancer is increased in passive smokers and in users of oral contraceptives with certain NBS1 genotypes. (Int J Biol Markers 2008; 23: 133-9)