ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
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DOI：
10.1016/j.tem.2016.12.001
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Herz J
中科院分区：
文献类型：
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作者：
Lane-Donovan C;Herz J
随着人口老龄化，神经退行性疾病，如阿尔茨海默病（AD），正在成为患者，他们的家庭和医疗保健系统的重大负担。神经退行性过程可能在AD的外在体征和症状之前长达15年开始，如AD患者和小鼠模型的数据所证明的。晚发型（AD）的一个主要遗传风险因素是载脂蛋白E（ApoE 4）的ε4亚型，约20%的人群中存在这种亚型。在这篇综述中，我们讨论了载脂蛋白E受体信号的贡献，三方突触的每个组件的功能-轴突终端，突触后树突棘，和星形胶质细胞-并检查这些系统如何在载脂蛋白E4和AD的背景下失败。
As the population ages, neurodegenerative diseases, such as Alzheimer’s disease (AD), are becoming a significant burden on patients, their families, and health care systems. Neurodegenerative processes may start up to fifteen years before outward signs and symptoms of AD, as evidenced by data from AD patients and mouse models. A major genetic risk factor for late-onset (AD) is the ε4 isoform of apolipoprotein E (ApoE4), which is present in almost 20% of the population. In this review, we discuss the contribution of ApoE receptor signaling to the function of each component of the tripartite synapse - the axon terminal, the post-synaptic dendritic spine, and the astrocyte - and examine how these systems fail in the context of ApoE4 and AD.