Expression of plasmolipin in the developing rat brain.
Expression of plasmolipin in the developing rat brain.
复制标题
发育中的大鼠大脑中血浆脂蛋白的表达。
DOI：
10.1002/jnr.490310114
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发表时间：
1992
影响因子：
4.2
通讯作者：
Fischer,I
中科院分区：
文献类型：
--
作者：
Sapirstein,VS;Nolan,CE;Stadler,II;Fischer,I
血浆磷脂是一种存在于肾脏和大脑中的疏水性质膜蛋白脂质。该蛋白由两个17-18.5 kD的亚基组成，它们共同形成K+选择性电压依赖性通道。在这份报告中，我们定义了胚胎和出生后的血浆磷脂在发育中的大鼠大脑中的表达。发现血浆磷脂基本上局限于出生后时期，出生后第一到第四周之间增加了8倍。胎儿血浆磷脂免疫反应蛋白（FPIP）被确定在胚胎脑，也在出生后早期发育的小脑。FPIP的表达是双相的，在E15-E20之间最初短暂增加，随后其水平降低。在发育的大鼠CNS中未检测到FPIP。FPIP存在于各种分裂和未成熟的细胞中，包括培养的星形细胞和胚胎神经元，神经母细胞瘤细胞和大鼠胸腺。与此相反，血浆磷脂仅限于测试的神经细胞的少突胶质细胞和肾小管上皮细胞。
Plasmolipin is an hydrophobic plasma membrane proteolipid present in both kidney and brain. The protein consists of two subunits of 17–18.5 kD, which together form K+selective voltage‐dependent channels. In this report, we define the embryonic and postnatal expression of plasmolipin in the developing rat brain. Plasmolipin was found to be essentially restricted to the postnatal period increasing eight‐fold between the first to fourth week after birth. A fetal plasmolipin immunoreactive protein (FPIP) was identified in embryonic brain and also during the early postnatal development of the cerebellum. The expression of FPIP was biphasic with an initial transient increase between E15‐E20 followed by a decrease in its levels. FPIP was not detected in the developed rat CNS. FPIP was found in a variety of dividing and immature cells including cultured astrdcytes and embryonic neurons, neuroblastoma cells, and rat thymus. In contrast, plasmolipin was restricted to oligodendrocytes of the neural cells tested and to renal tubular epithelial cells.