Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance.
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance.
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下丘脑 AMPK 作为能量平衡激素调节的中介
DOI：
10.3390/ijms19113552
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发表时间：
2018-11-11
影响因子：
5.6
通讯作者：
Cheng KK
中科院分区：
文献类型：
--
作者：
Wang B;Cheng KK
作为一种细胞能量感受器和调节器，一磷酸腺苷(AMP)激活的蛋白激酶(AMPK)在中枢神经系统(CNS)和外周器官的能量稳态调节中起着关键作用。下丘脑AMPK的激活通过诱导食欲增加食物摄入量和减少脂肪组织的适应性产热来维持能量平衡，从而减少对食物匮乏的能量消耗。许多代谢激素，如瘦素、脂联素、生长激素和胰岛素，通过与神经回路的整合，通过下丘脑AMPK发挥其能量调节作用。虽然AMPK在外周组织中的激活能够促进脂肪酸氧化和胰岛素敏感性，但它在下丘脑的长期激活通过诱导人类和啮齿动物的过度吞噬而导致肥胖。在这篇综述中，我们讨论了下丘脑AMPK在调节激素调节摄食和适应性产热中的作用，并总结了中枢AMPK维持能量动态平衡的各种潜在机制。
As a cellular energy sensor and regulator, adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both the central nervous system (CNS) and peripheral organs. Activation of hypothalamic AMPK maintains energy balance by inducing appetite to increase food intake and diminishing adaptive thermogenesis in adipose tissues to reduce energy expenditure in response to food deprivation. Numerous metabolic hormones, such as leptin, adiponectin, ghrelin and insulin, exert their energy regulatory effects through hypothalamic AMPK via integration with the neural circuits. Although activation of AMPK in peripheral tissues is able to promote fatty acid oxidation and insulin sensitivity, its chronic activation in the hypothalamus causes obesity by inducing hyperphagia in both humans and rodents. In this review, we discuss the role of hypothalamic AMPK in mediating hormonal regulation of feeding and adaptive thermogenesis, and summarize the diverse underlying mechanisms by which central AMPK maintains energy homeostasis.
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DOI：
10.1038/nrneurol.2017.185
发表时间：
2018-03
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Arnold SE;Arvanitakis Z;Macauley-Rambach SL;Koenig AM;Wang HY;Ahima RS;Craft S;Gandy S;Buettner C;Stoeckel LE;Holtzman DM;Nathan DM
通讯作者：
Nathan DM
影响因子：
15.9
作者：
Banno, Ryoichi;Zimmer, Derek;Bence, Kendra K.
通讯作者：
Bence, Kendra K.
影响因子：
64.5
作者：
Chen, H;Charlat, O;Morgenstern, JP
通讯作者：
Morgenstern, JP
影响因子：
8.1
作者：
Alvarez-Crespo M;Csikasz RI;Martínez-Sánchez N;Diéguez C;Cannon B;Nedergaard J;López M
通讯作者：
López M
影响因子：
4.8
作者：
Andersson, U;Filipsson, K;Small, CJ
通讯作者：
Small, CJ