Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium
Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium
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镰状网织红细胞上的α4β1-整合素表达：血管细胞粘附分子1依赖的与内皮的结合
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
TM Wick
中科院分区：
文献类型：
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作者：
R. Swerlick;J. Eckman;A. Kumar;M. Jeitler;TM Wick
镰状细胞性贫血的重要并发症继发于血管闭塞，推测血管闭塞是由红细胞与血管内皮细胞的相互作用引发的。在镰状细胞性贫血患者中，高达 25% 的网织红细胞表达 α4β1-整合素复合物。此外，来自镰状细胞性贫血患者的红细胞通过红细胞α4β1和内皮细胞血管细胞粘附分子1（VCAM-1）之间的相互作用与肿瘤坏死因子α（TNFα）激活的内皮细胞结合。因此，表达α4β1的网织红细胞与细胞因子激活的内皮细胞的结合可能引发镰状细胞性贫血以及感染和炎症发作期间的其他溶血性贫血的血管并发症。
Important complications in sickle cell anemia occur secondary to vascular occlusion, which is postulated to be initiated by interactions of erythrocytes with vascular endothelial cells. In patients with sickle cell anemia, up to 25% of reticulocytes express the alpha 4 beta 1-integrin complex. Furthermore, erythrocytes from patients with sickle cell anemia bind to endothelial cells activated by tumor necrosis factor alpha via (TNF alpha) via interactions between erythrocyte alpha 4 beta 1 and endothelial cell vascular cell adhesion molecule-1 (VCAM- 1). Thus, binding of alpha 4 beta 1-expressing reticulocytes to cytokine-activated endothelial cells may initiate vascular complications in sickle cell anemia and perhaps other hemolytic anemias during episodes of infection and inflammation.