Cross Currents in Protein Misfolding Disorders: Interactions and Therapy
Cross Currents in Protein Misfolding Disorders: Interactions and Therapy
复制标题
DOI：
10.2174/187152709789541998
复制
发表时间：
2009-11-01
影响因子：
3
通讯作者：
Soto, Claudio
中科院分区：
文献类型：
--
作者：
Morales, Rodrigo;Green, Kristi M.;Soto, Claudio
蛋白质错误折叠障碍（pmd）是一组以异常折叠蛋白质积累为特征的疾病。尽管涉及的蛋白质和组织范围广泛，但PMDs具有相似的分子和致病机制。一些流行病学、临床和实验报告描述了pmd的共存，表明它们之间可能存在串扰。更好地了解PMDs的分子基础可能对理解这些疾病出现和发展的机制以及最终制定新的治疗策略具有重要意义。由于它们相似的分子机制，共同的治疗策略可以应用于这一群体的疾病。
Protein Misfolding Disorders (PMDs) are a group of diseases characterized by the accumulation of abnormally folded proteins. Despite the wide range of proteins and tissues involved, PMDs share similar molecular and pathogenic mechanisms. Several epidemiological, clinical and experimental reports have described the co-existence of PMDs, suggesting a possible cross-talk between them. A better knowledge of the molecular basis of PMDs could have important implications for understanding the mechanisms by which these diseases appear and progress and ultimately to develop novel strategies for treatment. Due to their similar molecular mechanisms, common therapeutic strategies could be applied for the diseases in this group.