How to make beta cells?
How to make beta cells?
复制标题
如何制作β细胞？
DOI：
10.1016/j.ceb.2009.08.006
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发表时间：
2009-12
影响因子：
7.5
通讯作者：
Melton DA
中科院分区：
文献类型：
--
作者：
Borowiak M;Melton DA
糖尿病患者中产生胰岛素的 β 细胞丢失或数量不足，这给新 β 细胞带来了医学挑战。目前，三种策略有望实现。一种涉及通过引导胚胎干细胞或诱导多能细胞分化为 β 细胞谱系来从头生成 β 细胞。第二种是基于另一种终末分化细胞在称为重编程的过程中转化为β细胞。第三种方法是在体内或体外促进现有β细胞的复制。每项战略都取得了明显的重大进展，但尚不清楚哪种方法最终会取得成功。
Insulin-producing β cells are lost or insufficient in numbers in diabetic patients, presenting the medical challenge for new β cells. Currently, there are three strategies that offer promise. One involves the generation of β cells de novo by directing the differentiation of either embryonic stem cells or induced pluripotent cells to the β cell lineage. The second is based on the conversion of another terminally differentiated cell to β cells in a process called reprogramming. The third approach is to promote the replication of existing β cells either in vivo or in vitro. Significant progress is evident for each strategy, but it remains unclear which approach will ultimately prove successful.