Effect of MSC on the immune response of mice
Effect of MSC on the immune response of mice
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DOI：
10.1016/s0162-3109(99)00002-8
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发表时间：
1999-04-01
期刊：
影响因子：
--
通讯作者：
Szende, B
中科院分区：
文献类型：
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作者：
Hidvégi, M;Rásó, E;Szende, B
研究了假定的MSG的免疫刺激作用，MSG是一种新的发酵小麦胚芽提取物，标准化其苯醌成分（商品名：AVEMAR），检查用MSG处理的小鼠外周血淋巴细胞的母细胞转化。发现MSC显著增加由刀豆球蛋白A引起的胚细胞转化的程度。使用B10 LP至C（57）Bl皮肤移植系统，MSC（口服0.03和3.0 g kg（-1））有利于恢复免疫功能。另一方面，2，6-二甲氧基对苯醌（DMBQ），应用在等效剂量（0.012和1.2毫克/千克），并没有缩短皮肤移植排斥反应的时间。MSC的免疫恢复作用以及母细胞转化增强潜力可用于各种免疫应答降低的情况。(C)1999 Elsevier Science B. V.保留所有权利。
The supposed immunostimulatory actions of MSG, a new fermented wheat germ extract standardized to its benzoquinone composition (trade name: AVEMAR) were studied examining blastic transformation of peripheral blood lymphocytes of mice treated with MSG. It was found that MSC significantly increased the degree of blastic transformation caused by Concanavalin A. Using the B10LP to C(57)Bl skin graft system, MSC (0.03 and 3.0 g kg(-1) applied orally) acted in favour of restoring the immune function. On the other hand, 2,6-dimethoxy-p-benzoquinone (DMBQ), applied in equivalent doses (0.012 and 1.2 mg kg(-1)), did not shorten the rejection time of skin grafts. The immune restoring effect, as well as the blastic transformation enhancing potential of MSC may be exploited in various cases of decreased immune response. (C) 1999 Elsevier Science B.V. All rights reserved.