Expression and Proliferation‐Promoting Role of Diversin in the Neuronally Committed Precursor Cells Migrating in the Adult Mouse Brain
Expression and Proliferation‐Promoting Role of Diversin in the Neuronally Committed Precursor Cells Migrating in the Adult Mouse Brain
复制标题
Diversin 在成年小鼠大脑中神经元定向前体细胞迁移中的表达和增殖促进作用
作者：
Makiko Ikeda;Yuki Hirota;M. Sakaguchi;Osamu Yamada;Yasuyuki S. Kida;T. Ogura;T. Otsuka;H. Okano;K. Sawamoto
室管膜下区（SVZ）是成年啮齿动物大脑中最大的神经源性区域。在成人SVZ中，与胚胎脑不同，神经定向前体细胞（神经母细胞）在向嗅球（OB）迁移的同时保持其增殖活性，这表明它们被抑制退出细胞周期。关于成年成神经细胞在迁移过程中增殖的独特能力的机制知之甚少。在这里，我们研究了Diversin的表达和功能，Diversin是Wnt信号通路的一个组成部分。在新生和成年小鼠脑中，在SVZ和海马的成神经细胞和成熟神经元中观察到Diversin表达。逆转录病毒介导的Diversin过表达促进了成神经细胞的增殖，并增加了到达OB的成神经细胞的数量。相反，Diversin的敲低降低了成神经细胞的增殖。我们的研究结果表明，Diversin在成人脑SVZ的成神经细胞的增殖中起着重要作用。干细胞2010;28：2017-2026
The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In the adult SVZ, unlike in the embryonic brain, neuronally committed precursor cells (neuroblasts) maintain their proliferative activity while migrating toward the olfactory bulb (OB), suggesting that they are inhibited from exiting the cell cycle. Little is known about the mechanisms underlying the unique ability of adult neuroblasts to proliferate during migration. Here, we studied the expression and function of Diversin, a component of the Wnt signaling pathways. In the neonatal and adult mouse brain, Diversin expression was observed in neuroblasts and mature neurons in the SVZ and hippocampus. Retrovirus‐mediated overexpression of Diversin promoted the proliferation of neuroblasts and increased the number of neuroblasts that reached the OB. Conversely, the knockdown of Diversin decreased the proliferation of neuroblasts. Our results indicate that Diversin plays an important role in the proliferation of neuroblasts in the SVZ of the adult brain. STEM CELLS 2010;28:2017–2026
DOI：
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发表时间：
2008
期刊：
--
影响因子：
--
作者：
安達 一英
通讯作者：
安達 一英
DOI：
10.1016/j.msea.2012.05.070
发表时间：
2012-08-30
影响因子：
6.4
作者：
Jha, Gajendra;Das, Sourav;Haldar, Arunansu
通讯作者：
Haldar, Arunansu