Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review.
Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review.
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DOI：
10.1186/s13046-015-0278-7
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发表时间：
2016-01-08
期刊：
影响因子：
--
通讯作者：
Zhang SX
中科院分区：
文献类型：
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作者：
Belkacemi L;Zhang SX
色素上皮衍生因子（PEDF）是一种分泌型糖蛋白，是丝氨酸蛋白酶抑制剂（serpin）家族的非抑制性成员。它广泛表达于人胎儿和成人组织中，但其表达随着年龄的增长和恶性组织中而减少。PEDF的主要抗癌活性来自其双重作用，间接作用于肿瘤微环境（间接抗肿瘤作用）或直接作用于肿瘤本身（直接抗肿瘤影响）。PEDF的间接抗肿瘤活性是从早期发现中发现的，即它刺激视网膜母细胞瘤细胞分化，另外它具有抗血管生成、抗肿瘤生成和抗转移特性。然而，其直接抗肿瘤作用的机制尚未完全阐明。本文综述了PEDF多功能活性的研究进展，特别是其抗癌信号转导机制。此外，我们讨论了使用新型磷铂化合物作为癌症治疗的化疗药物的可能性，该化合物可以上调PEDF表达。
Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family. It is widely expressed in human fetal and adult tissues but its expression decreases with age and in malignant tissues. The main anti-cancer activities of PEDF derive from its dual effects, either indirectly on the tumor microenvironment (indirect antitumor action) or directly on the tumor itself (direct antitumor influence). The indirect antitumor activities of PEDF were uncovered from the early findings that it stimulates retinoblastoma cell differentiation and that additionally it possesses anti-angiogenic, anti-tumorigenic and anti-metastatic properties. The mechanisms of its direct antitumor effect, however, have not been fully elucidated. This review highlights recent progress in our understanding of the multifunctional activities of PEDF and, in particular, its anti-cancer signaling mechanisms. Additionally, we discuss the possibility of using novel phosphaplatin compounds that can upregulate PEDF expression as a chemotherapy for cancer treatment.