Clinical and Psychological Parameters Associated with Pain Pattern Phenotypes in Women with Interstitial Cystitis/Bladder Pain Syndrome
Clinical and Psychological Parameters Associated with Pain Pattern Phenotypes in Women with Interstitial Cystitis/Bladder Pain Syndrome
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DOI：
10.1016/j.juro.2014.07.108
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发表时间：
2015-01-01
影响因子：
6.6
通讯作者：
Tripp, Dean A.
中科院分区：
文献类型：
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作者：
Nickel, J. Curtis;Tripp, Dean A.
目的：最近提出，在泌尿系统慢性盆腔疼痛综合征患者中可以描述2种不同的临床表型，包括仅盆腔疼痛和盆腔疼痛以外。我们检查了间质性膀胱炎/膀胱疼痛综合征患者的数据，包括身体疼痛位置映射，以及相关的医学和心理社会表型，以验证接受三级护理的间质性膀胱炎/膀胱疼痛综合征女性患者队列中的这些身体疼痛图。材料和方法：来自173名诊断为间质性膀胱炎/膀胱疼痛综合征的门诊女性患者的有效问卷包括身体疼痛区域图，人口统计学/病史、疼痛评估、间质性膀胱炎/膀胱疼痛综合征症状、抑郁、焦虑、压力、疲劳、性功能、灾难性、生活质量和其他慢性疼痛状况的数据。两个疼痛表型的基础上的身体部位，盆腔疼痛，盆腔疼痛以外的计数，进行了全面的examined.Results：157例（81%）确定与盆腔疼痛以外的报告更多的感觉型疼痛，较差的身体生活质量，更大的躯体抑郁症和睡眠障碍比36（19%）仅与盆腔疼痛分类。仅盆腔疼痛组的性疼痛评分较高。此外，盆腔疼痛超出表型的患者报告了更高的患病率肠易激综合征和纤维肌痛，以及更一般的疲劳症状和精神conditions.Conclusions：两个不同的疼痛位置表型，包括盆腔疼痛，盆腔疼痛超出，我们的独立分析间质性膀胱炎/膀胱疼痛综合征的患者。基于疼痛模式评估临床表型对于我们更好地理解诊断为间质性膀胱炎/膀胱疼痛综合征的女性患者的病因和治疗具有重要意义。
Purpose: It was recently suggested that 2 distinct clinical phenotypes can be described in patients with urological chronic pelvic pain syndrome, including pelvic pain only and pelvic pain beyond. We examined data on patients with interstitial cystitis/bladder pain syndrome, including body pain location mapping, and associated medical and psychosocial phenotyping to validate these body pain maps in a cohort of female patients with interstitial cystitis/bladder pain syndrome undergoing tertiary care.Materials and Methods: Validated questionnaires from 173 diagnosed outpatient female patients with interstitial cystitis/bladder pain syndrome included a body pain area diagram, demographics/history, pain assessment, interstitial cystitis/bladder pain syndrome symptoms, depression, anxiety, stress, fatigue, sexual functioning, catastrophizing, quality of life and data on other chronic pain conditions. Two pain phenotypes based on counts of body locations, pelvic pain only and pelvic pain beyond, were comprehensively examined.Results: The 157 patients (81%) identified with pelvic pain beyond reported more sensory type pain, poorer physical quality of life, and greater somatic depression and sleep disturbance than the 36 (19%) categorized with pelvic pain only. The sexual pain score was higher in the pelvic pain only group. Furthermore, patients with the pelvic pain beyond phenotype reported a higher prevalence of irritable bowel syndrome and fibromyalgia as well as more general fatigue symptoms and psychiatric conditions.Conclusions: Two distinct pain location phenotypes, including pelvic pain only and pelvic pain beyond, were identified by our independent analysis of patients with interstitial cystitis/bladder pain syndrome. Assessing clinical phenotypes based on pain patterns has significant ramifications in our improved understanding of the etiology and treatment of female patients diagnosed with interstitial cystitis/bladder pain syndrome.