The cortical organization of audio-visual sentence comprehension: an fMRI study at 4 Tesla
The cortical organization of audio-visual sentence comprehension: an fMRI study at 4 Tesla
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DOI：
10.1016/j.cogbrainres.2003.10.014
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发表时间：
2004-07-01
期刊：
影响因子：
--
通讯作者：
Neville, HJ
中科院分区：
文献类型：
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作者：
Capek, CM;Bavelier, D;Neville, HJ
书面和口头句子处理的神经影像学研究报告更大的左半球比右半球激活。然而，我们对语言的绝大多数体验都是面对面的互动，这在信息上要丰富得多。本研究采用4特斯拉的功能性磁共振成像（fMRI）来研究视听（AV）句子处理的神经组织。参与者通过视频屏幕观看演讲者的面部和上半身，同时听她交替产生英语句子和由可发音的非单词组成的句子。视听句子加工与左半球Broca区、背外侧前额叶皮层、中央前沟上级区、外侧沟前部和中部、颞沟中部上级区、缘上回和角回的激活有关。此外，AV句子处理引起激活的右前和中外侧沟。半球间分析显示，左半球的激活模式占主导地位。研究结果支持了这一假设，即左半球可能偏向于处理语言独立的方式，通过它被感知。这些结果进行了讨论的背景下，以前的神经影像学结果使用美国手语（ASL）。(C)2004 Elsevier B.V.保留所有权利。
Neuroimaging studies of written and spoken sentence processing report greater left hemisphere than right hemisphere activation. However, a large majority of our experience with language is face-to-face interaction, which is much richer in information. The current study examines the neural organization of audio-visual (AV) sentence processing using functional magnetic resonance imaging (fMRI) at 4 Tesla. Participants viewed the face and upper body of a speaker via a video screen while listening to her produce, in alternating blocks, English sentences and sentences composed of pronounceable non-words. Audio-visual sentence processing was associated with activation in the left hemisphere in Broca's area, dorsolateral prefrontal cortex, the superior precentral sulcus, anterior and middle portions of the lateral sulcus, middle superior portions of the temporal sulcus, supramarginal gyrus and angular gyrus. Further, AV sentence processing elicited activation in the right anterior and middle lateral sulcus. Between-hemisphere analyses revealed a left hemisphere dominant pattern of activation. The findings support the hypothesis that the left hemisphere may be biased to process language independently of the modality through which it is perceived. These results are discussed in the context of previous neuroimaging results using American Sign Language (ASL). (C) 2004 Elsevier B.V. All rights reserved.