Acid-sensing ion channels contribute to the metaboreceptor component of the exercise pressor reflex.
Acid-sensing ion channels contribute to the metaboreceptor component of the exercise pressor reflex.
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酸感应离子通道有助于运动加压反射的代谢感受器成分。
DOI：
10.1152/ajpheart.00328.2009
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Kaufman,MarcP
中科院分区：
文献类型：
--
作者：
McCord,JenniferL;Tsuchimochi,Hirotsugu;Kaufman,MarcP
运动升压反射是由骨骼肌收缩时产生的机械刺激和代谢刺激引起的。最近，用阿米洛利和A-316567阻断酸敏感离子通道(ASIC)可减弱反射。此外，阿米洛利对反射的机械感受器成分没有影响，这促使我们确定ASICs是否对运动加压反射的代谢物感受器成分有贡献。当只刺激代谢物受体时，可以通过测量收缩后循环闭塞期间的平均动脉压来评估代谢物受体成分。我们观察了阿米洛利(0.5μg/kg)、A-317567(10 mM，0.5ml)和生理盐水(0.5ml)对30只去大脑猫阻断循环时静态收缩后升压反应的影响。将阿米洛利(n=11)和A-317567(n=7)注入小腿三头肌的动脉血供，可减弱循环阻断时收缩和收缩后循环阻断的升压反应(P<0.05)。然而，生理盐水(n=11)对循环闭塞时收缩或收缩后循环闭塞的升压反应没有影响(P>；0.79)。我们的发现使我们得出结论，ASIC对运动加压反射的代谢物受体成分有贡献。
The exercise pressor reflex is evoked by both mechanical and metabolic stimuli arising in contracting skeletal muscle. Recently, the blockade of acid-sensing ion channels (ASICs) with amiloride and A-316567 attenuated the reflex. Moreover, amiloride had no effect on the mechanoreceptor component of the reflex, prompting us to determine whether ASICs contributed to the metaboreceptor component of the exercise pressor reflex. The metaboreceptor component can be assessed by measuring mean arterial pressure during postcontraction circulatory occlusion when only the metaboreceptors are stimulated. We examined the effects of amiloride (0.5 μg/kg), A-317567 (10 mM, 0.5 ml), and saline (0.5 ml) on the pressor response to and after static contraction while the circulation was occluded in 30 decerebrated cats. Amiloride (n= 11) and A-317567 (n= 7), injected into the arterial supply of the triceps surae muscles, attenuated the pressor responses both to contraction while the circulation was occluded and to postcontraction circulatory occlusion (all,P< 0.05). Saline (n= 11), however, had no effect on the pressor responses to contraction while the circulation was occluded or to postcontraction circulatory occlusion (both,P> 0.79). Our findings led us to conclude that ASICs contribute to the metaboreceptor component of the exercise pressor reflex.