Gastric histamine metabolism and acid secretion in rats as influenced by diet and nutrient content.
Gastric histamine metabolism and acid secretion in rats as influenced by diet and nutrient content.
复制标题
大鼠胃组胺代谢和酸分泌受饮食和营养素含量的影响。
DOI：
10.1093/jn/113.2.379
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
H. Fisher
中科院分区：
文献类型：
--
作者：
S. C. Chen;H. Fisher
给大鼠喂食含有白色、酪蛋白、鲱鱼粉、大豆蛋白或小麦面筋的饮食，以评估饮食蛋白（和其他营养素）对胃功能的影响。鲱鱼粉组表现出增加胃组氨酸脱羧酶（HDC）活性，组胺浓度，以及酸分泌与对照组相比，酪蛋白组。当大鼠喂食补充氨基酸的酪蛋白或鱼粉饮食，以模拟对方的氨基酸谱，胃HDC活性，组胺含量和酸分泌的小幅增加，观察到与未补充酪蛋白或鱼粉组相比。高矿物质含量的鲱鱼粉（15%）被认为是胃组胺代谢和胃酸分泌的潜在诱导因素。添加鱼粉灰酪蛋白饮食或鳕鱼鱼片饮食升高胃HDC活性和组胺浓度显着。此外，当钙（Ca）添加到酪蛋白饮食，以模拟其高含量的鲱鱼鱼粉（7.8%），类似的升高水平的胃组胺得到的钙补充酪蛋白组的鱼粉组。Ca的作用可能是由于胃泌素的释放，从而导致胃组胺的释放，或通过促进肥大细胞组氨酸掺入随后的组胺合成。
Diets containing egg white, casein, menhaden fish meal, soy protein or wheat gluten were fed to rats to assess the impact of dietary protein (and other nutrients) on gastric functions. The menhaden fish meal group exhibited increases in stomach histidine decarboxylase (HDC) activity, histamine concentration, as well as acid secretion when compared with the control, casein group. When rats were fed amino acid-supplemented casein or fish meal diets to simulate each other's amino acid profile, a small increase in gastric HDC activity, histamine content and acid secretion was observed in comparison with the unsupplemented casein or fish meal groups. The high mineral content of menhaden fish meal (15%) was thought to be a potential inducing factor for gastric histamine metabolism and acid secretion. Adding fish meal ash to the casein diet or to a cod fillet diet elevated stomach HDC activity and histamine concentration significantly. Furthermore, when calcium (Ca) was added to the casein diet to simulate its high content in menhaden fish meal (7.8%), similar elevated levels of gastric histamine were obtained for the Ca-supplemented casein group as for the fish meal group. The role of Ca could be due to release of gastrin, which results in release of stomach histamine, or by facilitating mast cell histidine incorporation with subsequent histamine synthesis.