What are the clinical consequences of anemia in patients with chronic heart failure?
What are the clinical consequences of anemia in patients with chronic heart failure?
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DOI：
10.1016/j.cardfail.2004.01.001
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发表时间：
2004-02-01
影响因子：
6
通讯作者：
McMurray, JJV
中科院分区：
文献类型：
--
作者：
McMurray, JJV
最近的研究引起了心脏病学家对慢性心力衰竭患者贫血的潜在影响的关注。累积的研究表明贫血和较差的功能状态以及发病率和死亡率增加之间的关联。有数据支持贫血与更差的纽约心脏协会功能分级、更差的运动能力和更高的住院率相关。贫血也被证明是慢性心力衰竭患者生存的独立预测因素。然而，贫血可能增加慢性心力衰竭风险的确切病理生理机制尚不清楚。同样，临床医生还没有任何证据表明贫血和这些参数之间是否存在真正的因果关系。只有旨在纠正贫血和评估对临床结果影响的干预研究才能验证这些重要假设。
Recent studies have drawn cardiologists' attention to the potential impact of anemia in chronic heart failure patients. Cumulative studies show the association between anemia and poorer functional status and increased morbidity and mortality. There are data supporting the association of anemia with worse New York Heart Association functional class, poorer exercise capacity, and increased hospital admission. Anemia has also been shown to be an independent predictor of survival in patients with chronic heart failure. However, the precise pathophysiologic mechanisms by which anemia may increase risk in chronic heart failure are unknown. Similarly, clinicians do not yet have any evidence of whether there is or not a true cause-and-effect relationship between anemia and these parameters. Only intervention studies intended to correct anemia and evaluate the effect on clinical outcomes can verify these important hypotheses.