Activation of immediate early genes after acute stress.
Activation of immediate early genes after acute stress.
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急性应激后立即早期基因的激活。
DOI：
10.1097/00001756-199101000-00004
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发表时间：
1991
期刊：
影响因子：
1.7
通讯作者：
Thompson,RF
中科院分区：
文献类型：
--
作者：
Schreiber,SS;Tocco,G;Shors,TJ;Thompson,RF
我们使用原位杂交来研究急性应激对大鼠大脑中立即早期基因 (IEG)、c-fos 和 zif/268 诱导的影响。经过一小时的束缚加上间歇性尾部电击后，双侧新皮质中这两种基因的信使 RNA (mRNA) 水平显着增加，特别是在 IV、V 和 VI 层以及海马 CA1 区域。这种区域特异性反应表明 IEG 可能在中枢神经系统急性应激反应的调节中发挥作用。
WE used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.