Clinical Trial Methodology of Pain Treatment Studies Selection and Measurement of Self-Report Primary Outcomes for Efficacy
Clinical Trial Methodology of Pain Treatment Studies Selection and Measurement of Self-Report Primary Outcomes for Efficacy
复制标题
DOI：
10.1097/aap.0b013e318217a635
复制
发表时间：
2011-07-01
影响因子：
5.1
通讯作者：
Jensen, Mark P.
中科院分区：
文献类型：
--
作者：
Gilron, Ian;Jensen, Mark P.
在过去的世纪中，在评估急性和慢性疼痛治疗干预的有效性的方法学方面取得了巨大的进步。持续的挑战围绕着如何最好地选择和衡量一个给定的镇痛试验的主要疗效结果。认识到疼痛的复杂性，多方面的，感觉和情感的性质，并应用心理测量技术，促进了几个有效和可靠的自我报告措施，评估疼痛强度，疼痛缓解，和其他重要的结果域相关的疼痛治疗的发展。在制定新的疼痛治疗策略时，必须仔细考虑将当前或新的结局指标与拟议试验的具体目标相匹配。未来的研究需要直接比较当前的方法与新的测量方法，以最大限度地提高疼痛治疗临床试验中不同结局测量的有效性、可靠性和实用性。
The past century has seen immense progress in the advancement of methodology to evaluate efficacy of treatment interventions for acute and chronic pain. Continuing challenges revolve around how to best select and measure primary efficacy outcomes for a given analgesic trial. Recognizing the complex, multidimensional, sensory and emotional nature of pain and applying psychometric techniques have facilitated the development of several valid and reliable self-report measures that evaluate pain intensity, pain relief, and other important outcome domains relevant to pain treatment. In the setting of emerging new pain treatment strategies, careful consideration must be given to match current or novel outcome measures to the specific goals of a proposed trial. Future research is needed to directly compare current methods with newer measurement approaches for the critical goal of maximizing validity, reliability, and utility of different outcome measures in clinical trials of pain treatment.