Atherosclerosis: the eicosanoid connection
Atherosclerosis: the eicosanoid connection
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DOI：
10.1007/bf00229585
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发表时间：
1992-04
影响因子：
4.3
通讯作者：
A. Makheja
中科院分区：
文献类型：
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作者：
A. Makheja
这张鸟瞰图展示了代谢短暂的局部激素（统称为类花生酸）和动脉粥样硬化性心血管疾病之间的联系。讨论将围绕冠状动脉粥样硬化的概述，重点是动脉粥样硬化病变形成的序列;含氧脂肪酸环氧合酶和脂氧合酶产物-类花生酸的结构和历史背景;环氧合酶形成内过氧化物过程中自由基的产生;类花生酸参与动脉粥样硬化炎症过程，最后，非甾体和甾体抗炎药对类花生酸合成和实验性动脉粥样硬化的影响。关于类花生酸在动脉粥样硬化发生中的确切作用知之甚少。
This bird's eye view presents connections between the metabolically short-lived local hormones (collectively known as eicosanoids) and atherosclerotic cardiovascular disease. The discussion will be centered around an overview of coronary atherosclerosis with an emphasis on the sequences involved in the formation of atherosclerotic lesions; structure and historical background of oxygenated fatty acids cyclooxygenase and lipoxygenase products — eicosanoids; the generation of free radicals during the formation of endoperoxides by cyclooxygenase; the involvement of eicosanoids in the atherosclerotic inflammatory process, and finally, the effects of non-steroidal and steroidal anti-inflammatory drugs on the synthesis of eicosanoids and experimental atherosclerosis. Little is known about the exact role of eicosanoids in the genesis of atherosclerosis.