Novel axially chiral bis-arylthiourea-based organocatalysts for asymmetric Friedel-Crafts type reactions
Novel axially chiral bis-arylthiourea-based organocatalysts for asymmetric Friedel-Crafts type reactions
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DOI：
10.1016/j.tetlet.2006.07.112
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发表时间：
2006-09-25
影响因子：
1.8
通讯作者：
Connon, Stephen J.
中科院分区：
文献类型：
--
作者：
Fleming, Eimear M.;McCabe, Thomas;Connon, Stephen J.
研究表明，催化量（10-20 mol%）的新型轴向手性双芳基硫脲可促进吲哚和 N-甲基吲哚与硝基烯烃的不对称有机催化弗瑞德-克来福特型加成。最佳催化剂能够促进具有挑战性的底物（例如N-甲基吲哚和带有脂肪族β-取代基的硝基烯烃）之间的反应，并具有有机催化系统前所未有的对映选择性。 (c) 2006 Elsevier Ltd. 保留所有权利。
It has been shown that catalytic amounts (10-20 mol %) of novel axially chiral bis-arylthioureas promote the asymmetric organocatalytic Friedel-Crafts type addition of indole and N-methylindole to nitroolefins. The optimum catalyst is capable of promoting the reaction between challenging substrates such as N-methylindole and nitroolefins bearing aliphatic beta-substituents with enantioselectivity unprecedented for an organocatalytic system. (c) 2006 Elsevier Ltd. All rights reserved.