Calcium and sodium transport in the duodenum of the Dahl salt sensitive and salt resistant rat.
Calcium and sodium transport in the duodenum of the Dahl salt sensitive and salt resistant rat.
复制标题
达尔盐敏感和耐盐大鼠十二指肠中的钙和钠转运。
DOI：
10.1097/00004872-198805000-00014
复制
发表时间：
1988
影响因子：
4.9
通讯作者：
Reeves,CP
中科院分区：
文献类型：
--
作者：
Schedl,HP;Wilson,HD;Reeves,CP
我们测定了雌性达尔盐敏感（DS）和耐盐（DR）大鼠的摄食量、身体生长和十二指肠钙钠转运。食用0.4%和8%氯化钠的DS大鼠和DR大鼠的食物摄入量和身体生长相似。食物摄入量随着年龄的增长而增加，直到5周，然后保持不变，尽管身体继续生长。在6周和11周饲喂0.4%氯化钠的大鼠和6周饲喂8%氯化钠的大鼠比较，DS组和DR组钙和钠的转运相同。在第11周时，钙的转运比第6周时要低，而不是钠的转运。6周龄DS大鼠和DR大鼠同时饲喂0.4%或8%氯化钠饲料，相比于0.4%氯化钠饲料，饲喂8%氯化钠饲料的大鼠钙转运倾向较低，DR大鼠净钙转运差异显著。8%氯化钠喂养的DS大鼠收缩压高于DR大鼠。我们得出结论，生长中的DS大鼠和DR大鼠在摄入等量食物的情况下，通过外翻囊技术测量的十二指肠钙和钠运输没有差异。不同品系对饲喂氯化钠的反应不同：高盐日粮降低了DR品系的净钙转运，而DS品系没有。
We measured food intake, body growth and transport of calcium and sodium by duodenum of female Dahl salt sensitive (DS) and salt resistant (DR) rat strains. Food intake and body growth were similar for DS and DR rats taking both 0.4 and 8% sodium chloride diets. Food intake increased with age up to 5 weeks and then remained constant despite continuing body growth. Comparing DS and DR rats fed the 0.4% sodium chloride diet at 6 and 11 weeks or the 8% sodium chloride diet at 6 weeks, transport of calcium and sodium were the same in both the DS and DR groups. Transport of calcium, but not sodium, was lower at 11 than at 6 weeks. Comparing simultaneous feeding of either 0.4 or 8% sodium chloride diets to 6-week old DS and DR rat strains, transport of calcium tended to be lower in animals fed the 8% as compared to the 0.4% sodium chloride diet, and the difference was significant for net 40Ca transport for DR rats. The DS rat fed on 8% sodium chloride had higher systolic blood pressure (SBP) than the DR rat. We conclude that growing DS and DR rats, ingesting equal amounts of food, do not differ in duodenal calcium and sodium transport measured by the everted sac technique. The response to feeding sodium chloride differs between strains: the high salt diet decreases net 40Ca transport in the DR but not the DS strain.