A proposed role for neutrophil extracellular traps in cancer immunoediting.
A proposed role for neutrophil extracellular traps in cancer immunoediting.
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DOI：
10.3389/fimmu.2013.00048
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发表时间：
2013
影响因子：
7.3
通讯作者：
Zychlinsky A
中科院分区：
文献类型：
--
作者：
Berger-Achituv S;Brinkmann V;Abed UA;Kühn LI;Ben-Ezra J;Elhasid R;Zychlinsky A
在激活时，中性粒细胞释放由染色质和中性粒细胞蛋白组成的纤维，称为中性粒细胞胞外陷阱（NET）。NET捕获并杀死微生物，激活树突状细胞和T细胞，并与自身免疫和血管疾病有关。鉴于人们对中性粒细胞在癌症免疫编辑中的作用和NET的多样功能越来越感兴趣，我们搜索了肿瘤相关中性粒细胞（TAN）释放的NET。以儿童尤文肉瘤（ES）为模型，我们回顾性检查了8例患者（平均± SD年龄为11.5 ± 4.7岁）诊断性活检的组织病理学材料。在6名患者中发现了TAN，其中2名我们发现了NET。这两名患者表现为转移性疾病，尽管在强化化疗后进入完全缓解，但早期复发。在两名局部疾病患者和两名转移性疾病患者的诊断性活检中未发现NET。这项研究首次表明ES中的TAN被激活以产生NET，指出了NET在癌症中的可能作用。
Upon activation, neutrophils release fibers composed of chromatin and neutrophil proteins termed neutrophil extracellular traps (NETs). NETs trap and kill microbes, activate dendritic cells and T cells, and are implicated in autoimmune and vascular diseases. Given the growing interest in the role of neutrophils in cancer immunoediting and the diverse function of NETs, we searched for NETs release by tumor-associated neutrophils (TANs). Using pediatric Ewing sarcoma (ES) as a model, we retrospectively examined histopathological material from diagnostic biopsies of eight patients (mean ± SD age of 11.5 ± 4.7 years). TANs were found in six patients and in two of those we identified NETs. These two patients presented with metastatic disease and despite entering complete remission after intensive chemotherapy had an early relapse. NETs were not identified in the diagnostic biopsies of two patients with localized disease and two with metastatic disease. This study is the first to show that TANs in ES are activated to make NETs, pointing to a possible role of NETs in cancer.
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DOI：
10.1158/1078-0432.ccr-10-0735
发表时间：
2010-08-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cho D;Shook DR;Shimasaki N;Chang YH;Fujisaki H;Campana D
通讯作者：
Campana D
影响因子：
50.3
作者：
Granot Z;Henke E;Comen EA;King TA;Norton L;Benezra R
通讯作者：
Benezra R
影响因子：
11.2
作者：
Mittendorf EA;Alatrash G;Qiao N;Wu Y;Sukhumalchandra P;St John LS;Philips AV;Xiao H;Zhang M;Ruisaard K;Clise-Dwyer K;Lu S;Molldrem JJ
通讯作者：
Molldrem JJ
影响因子：
11.2
作者：
Acuff, HB;Carter, KJ;Matrisian, LM
通讯作者：
Matrisian, LM
影响因子：
6.4
作者：
Brinkrolf, Peter;Landmeier, Silke;Rossig, Claudia
通讯作者：
Rossig, Claudia