STUDIES ON HUMAN BASOPHIL RELEASABILITY
STUDIES ON HUMAN BASOPHIL RELEASABILITY
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DOI：
10.1159/000233761
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
BONINI, S
中科院分区：
文献类型：
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作者：
MARONE, G;POTO, S;BONINI, S
嗜碱性粒细胞释放性是几种病理生理条件下的重要参数。在正常供体中，组胺释放的最大百分比和细胞对兔抗Fc ε（抗IgE）的敏感性与细胞供体的年龄相关。20岁以下受试者血清IgE水平与抗IgE诱导的组胺释放呈正相关。60岁以上受试者对甲酰-Met-Leu-Phe（f-met肽）的反应显著降低。在双胞胎中，IgE介导的释放性和血清IgE水平似乎是由两种不同的遗传机制控制。特应性皮炎患者的嗜碱性粒细胞对抗IgE的反应比年龄匹配的对照组更敏感。
Basophil releasability is an important parameter in several pathophysiological conditions. In normal donors, the maximum percent histamine release and cell sensitivity to rabbit anti-Fcε(anti-IgE) is correlated with the age of cell donors. A positive correlation between serum IgE level and anti-IgE-induced histamine release was found in subjects below 20 years old. The response to formyl-Met-Leu-Phe (f-met peptide) was significantly reduced in subjects above 60 years old. In twins, IgE-mediated releasability and serum IgE levels appear to be controlled by two different genetic mechanisms. Basophils of patients with atopic dermatitis were more responsive than those of control subjects of matched ages to anti-IgE.