Contribution of Microdosimetry to the Specification of Neutron Beam Quality for the Choice of the 'Clinical RBE' in Fast Neutron Therapy
Contribution of Microdosimetry to the Specification of Neutron Beam Quality for the Choice of the 'Clinical RBE' in Fast Neutron Therapy
复制标题
微剂量测定法对中子束质量规范的贡献，以选择快中子治疗中的“临床 RBE”
DOI：
10.1093/oxfordjournals.rpd.a082233
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发表时间：
1994
影响因子：
1
通讯作者：
A. Wambersie
中科院分区：
文献类型：
--
作者：
A. Wambersie
本文讨论了中子治疗中的相对生物有效性(RBE)问题及其目前的处理方法。提出了微剂量学对改善这一状况的可能贡献。在高LET放射治疗中，必须考虑和明确辐射质量和辐射质量差异。在快中子治疗中，采用了一种基于“临床RBE”概念的可操作性方法。本文讨论了放射治疗中RBE、参考RBE和临床RBE的数量及其相互关系和意义。特别是阐明和强调了放射生物学中明确定义的RBE与以放射治疗师的判断为基础的临床RBE的区别。虽然它首先是基于参考的RBE，但临床RBE隐含地包括了放射束的物理选择性以及临床经验(如果有)的差异。微剂量学可以通过描述感兴趣点的辐射质量，为临床RBE的选择提供有用的信息。已经发展了一种方法，使用迭代和反卷积技术，在微剂量谱可用的情况下，允许推导给定的新中子束的RBE。这种方法已经通过结合微剂量学数据和在九个中子治疗束上获得的放射生物学数据(肠道隐窝细胞再生)进行了测试。对于“新的”中子束，根据微剂量谱计算的RBE值将具有与直接测量的RBE值相同的精度(和置信度)。系统获得的晚期正常组织耐受性的放射生物学数据仍然缺失；它们与微剂量学数据的相关性将与临床应用最相关。
This paper discusses the Relative Biological Effectiveness (RBE) problem in neutron therapy and the way it is handled today. The possible contribution of microdosimetry to improve the situation is suggested. In high LET radiation therapy, radiation quality and radiation quality differences have to be taken into account and specified. In fast neutron therapy, an operational approach has been adopted which is based on the concept of 'clinical RBE'. The paper discusses the quantities of RBE, reference RBE and clinical RBE, their relationship and significance in radiation therapy. In particular, the difference between the well-defined RBE in radiation biology and the clinical RBE which is based on the judgement of radiotherapists are elucidated and emphasised. Although it is based first on the reference RBE, the clinical RBE implicitly includes differences in physical selectivity of the irradiation beam as well as clinical experience when available. Microdosimetry can provide useful information for the selection of the clinical RBE by giving a description of the radiation quality at the point of interest. A method has been developed, using iterative and deconvolution techniques, allowing the derivation of the RBE of a given new neutron beam provided the microdosimetric spectra are available. This method has been tested by combining microdosimetric data and radiobiological data (intestinal crypt cell regeneration) obtained at nine neutron therapy beams. For a 'new' neutron beam, the RBE value computed on the basis of the microdosimetric spectra would have the same accuracy (and confidence) as RBE values measured directly. Radiobiological data, systematically obtained for late normal tissue tolerance at 2 Gy per fraction, are still missing; their correlation with the microdosimetric data would be most relevant for clinical applications.