Untangling chromatin interactions.
Untangling chromatin interactions.
复制标题
解开染色质相互作用。
DOI：
10.1093/jxb/eraa334
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发表时间：
2020
影响因子：
6.9
通讯作者：
Parry G
中科院分区：
文献类型：
--
作者：
Parry G
5116|在有丝分裂和减数分裂期间NE的分解和随后的重组过程中NE组分的编辑作用。在有丝分裂过程中，NE蛋白可以与细胞板结合或围绕染色质，在后一种情况下，可能有助于细胞分裂后NE-染色质相互作用的正确重组。在减数分裂期间，端粒在NE处组装成花束结构，其精确形成在植物物种之间不同。Fernán-Jiménez和Pradillo（2020）比较了玉米、拟南芥、小麦和水稻中的这些过程。桑托斯等人（2020）更广泛地研究核结构域与基因表达调控之间的关系。关于所谓的“核体”的已发表报告越来越多，它们被描述为酶促反应的位置，也被描述为蛋白质的螯合，储存，修饰，回收或降解。这些可以是永久性的结构，例如核仁，或者可以在特定的环境应力下形成。直到最近，核体的形成机制还不清楚，但桑托斯等。（2020）综述了来自哺乳动物实验系统和最近在拟南芥中的文献，这些文献表明它们可能通过内在无序结构域蛋白的相互作用通过液-液相分离（LLPS）形成。LLPS在哺乳动物细胞中的潜在作用的介绍是埃尔埃斯科里亚会议的一个亮点，由德累斯顿马克斯普朗克分子细胞生物学和遗传学研究所的Adam Klosin介绍（Klosin et al.，2020年）。未来的研究可能会揭示，由LLPS介导的物理变化将定义其他核隔间之间的拓扑关系。
5116| Special Issue Editorial role of NE components during the breakdown and subsequent reassembly of the NE during mitosis and meiosis. During mitosis, NE proteins can either associate with the cell plate or surround the chromatin, in the latter case presumably facilitating the correct reassembly of NE–chromatin interactions following cell division. During meiosis, the telomeres assemble at the NE in a bouquet structure, the precise formation of which differs between plant species. Fernández-Jiménez and Pradillo (2020) compare these processes in maize, Arabidopsis, wheat, and rice. Santos et al.(2020) take a broader look at the relationship between nuclear domains and regulation of gene expression. Published reports about so-called ‘nuclear bodies’ are increasing and they are described as the location of enzymatic reactions and also the sequestration, storage, modification, recycling, or degradation of proteins. These can be permanent structures, such as the nucleolus, or can form under particular environmental stresses. Until recently, the mechanism of formation of nuclear bodies was unknown, but Santos et al.(2020) review literature from both mammalian experimental systems and more recently in Arabidopsis that suggests that they may be formed by liquid–liquid phase separation (LLPS) through the interaction of intrinsically disordered domain proteins. Introduction to the potential role of LLPS in mammalian cells was a highlight of the El Escorial meeting as introduced by Adam Klosin from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden (Klosin et al., 2020). Future research might reveal that the physical changes mediated by LLPS will define the topological relationships between other nuclear compartments.
影响因子：
9.4
作者：
Pellicer, Jaume;Leitch, Ilia J.
通讯作者：
Leitch, Ilia J.