POSTNATAL-DEVELOPMENT OF THE BRUSH CELLS IN THE COMMON BILE-DUCT OF THE RAT
POSTNATAL-DEVELOPMENT OF THE BRUSH CELLS IN THE COMMON BILE-DUCT OF THE RAT
复制标题
DOI：
10.1007/bf00318592
复制
发表时间：
1991-12-01
影响因子：
3.6
通讯作者：
ISEKI, S
中科院分区：
文献类型：
--
作者：
ISEKI, S
本实验观察了大鼠胆总管远端刷状细胞的生后发育过程，观察了刷状细胞的数量和肝脂肪酸结合蛋白（L-FABP）的免疫反应性。 生后4周，胆总管中首次出现刷状细胞，扫描电镜下可与主细胞区分开来。 它们的数量显著增加，时间上存在性别差异，即，雄性为8 - 12周，雌性为10 - 14周。 在两种性别中，刷状细胞的频率在16周龄时达到总上皮细胞的约30%，并保持恒定，直到40周龄。 L-FABP免疫反应阳性的细胞在8周时首次出现在少数。 免疫电镜显示免疫反应阳性细胞均为刷状细胞。 16 ~ 40周时，其数量逐渐增加，无性别差异。 在40周时，免疫反应细胞达到总上皮细胞的约7.5%，相当于刷状细胞数量的四分之一。 这些结果表明，在胆总管刷状细胞群的发生是一个晚期事件在出生后的发展，其功能的成熟与年龄的进展。
The postnatal development of brush cells in the distal segment of the common bile duct of the rat was examined with respect to cell number and immunoreactivity for liver fatty acid-binding protein (L-FABP). The brush cells, distinguishable from the principal cells by scanning electron microscopy, first appeared in the common bile duct 4 weeks after birth. They showed a remarkable increase in number, with a sex difference in time, i.e., between 8 and 12 weeks in the male and between 10 and 14 weeks in the female. In both sexes, the frequency of brush cells reached approximately 30% of total epithelial cells by 16 weeks and remained constant until 40 weeks of age. Cells with positive immunoreactivity for L-FABP first appeared in small numbers at 8 weeks. Immuno-electron microscopy revealed that all immunoreactive cells were brush cells. They increased in number gradually from 16 to 40 weeks with no sex difference. At 40 weeks, the immunoreactive cells reached approximately 7.5% of total epithelial cells, corresponding to one-fourth of the number of brush cells. These results indicate that the occurrence of the brush cell population in the common bile duct is a late event in the postnatal development of the rat and that its functional maturation progresses with aging.