Allelic Variation of Risk for Anxiety Symptoms Moderates the Relation Between Adolescent Safety Behaviors and Social Anxiety Symptoms.
Allelic Variation of Risk for Anxiety Symptoms Moderates the Relation Between Adolescent Safety Behaviors and Social Anxiety Symptoms.
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DOI：
10.1007/s10862-015-9488-8
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发表时间：
2015-12-01
影响因子：
1.6
通讯作者：
De Los Reyes A
中科院分区：
文献类型：
--
作者：
Thomas SA;Weeks JW;Dougherty LR;Lipton MF;Daruwala SE;Kline K;De Los Reyes A
社交焦虑通常在青春期出现，并且先于抑郁症和药物滥用障碍的发作。社交焦虑与使用行为来尽量减少社交场合的痛苦（即安全行为）之间的联系很强，对于一些患者来说，这种联系给参与基于暴露的治疗并从中受益带来了困难。然而，关于个体差异是否可以调节社交焦虑和安全行为之间的联系（即与焦虑密切相关的遗传等位基因的变化），人们知之甚少。我们研究了青少年社交焦虑与安全行为表达之间的关系，以及焦虑的等位基因变异是否调节了这种关系。青少年（n=75；年龄 14-17 岁）是从两项调查家庭关系或青少年社交焦虑测量的大型研究中招募的。青少年完成了有关社交焦虑症状和安全行为使用的自我报告措施。他们还提供了唾液样本来评估两种基因多态性（BDNF rs6265；TAQ1A rs1800497）导致焦虑的等位基因变异。控制青少年年龄和性别，我们观察到社交焦虑症状和等位基因变异之间存在显着的相互作用（β=0.37，t=2.41，p=.02）。具体而言，携带焦虑等位基因变异的青少年在社交焦虑症状和安全行为之间表现出统计上显着且相对较强的正相关关系（β=0.73），而未携带等位基因变异的青少年则表现出统计上不显着且相对较弱的关系（β=0.22）。这些发现对于治疗青少年社交焦虑具有重要意义，因为我们确定了一个个体差异变量，可用于识别那些证明使用安全行为和表达社交焦虑之间存在特别密切联系的人。
Social anxiety often develops in adolescence, and precedes the onset of depression and substance use disorders. The link between social anxiety and use of behaviors to minimize distress in social situations (i.e., safety behaviors) is strong and for some patients, this link poses difficulty for engaging in, and benefiting from, exposure-based treatment. Yet, little is known about whether individual differences may moderate links between social anxiety and safety behaviors, namely variations in genetic alleles germane to anxiety. We examined the relation between adolescent social anxiety and expressions of safety behaviors, and whether allelic variation for anxiety moderates this relation. Adolescents (n=75; ages 14–17) were recruited from two larger studies investigating measurement of family relationships or adolescent social anxiety. Adolescents completed self-report measures about social anxiety symptoms and use of safety behaviors. They also provided saliva samples to assess allelic variations for anxiety from two genetic polymorphisms (BDNF rs6265; TAQ1A rs1800497). Controlling for adolescent age and gender, we observed a significant interaction between social anxiety symptoms and allelic variation (β=0.37, t=2.41, p=.02). Specifically, adolescents carrying allelic variations for anxiety evidenced a statistically significant and relatively strong positive relation between social anxiety symptoms and safety behaviors (β=0.73), whereas adolescents not carrying allelic variation evidenced a statistically non-significant and relatively weak relation (β=0.22). These findings have important implications for treating adolescent social anxiety, in that we identified an individual difference variable that can be used to identify people who evidence a particularly strong link between use of safety behaviors and expressing social anxiety.