COUPLED TRANSPORT OF SOLUTE AND WATER ACROSS RABBIT GALLBLADDER EPITHELIUM.
COUPLED TRANSPORT OF SOLUTE AND WATER ACROSS RABBIT GALLBLADDER EPITHELIUM.
复制标题
溶质和水在兔胆囊上皮中的耦合运输。
DOI：
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发表时间：
1964
影响因子：
15.9
通讯作者：
H. O. Wheeler
中科院分区：
文献类型：
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作者：
R. T. Whitlock;H. O. Wheeler
Diamond（2-4）最近对离体鱼胆囊的研究表明，氯化钠的主动电中性转运为胆囊腔吸收水提供了驱动力。水的吸收耦合到主动溶质运输的程度表明了对跨胆囊壁的显着渗透梯度的净吸水的演示。在离体兔胆囊研究中报告了类似的发现（5），其中还证明碳酸氢盐参与了主动溶质转运。Grim（6）在体内犬胆囊中证明了水逆渗透梯度的运输，他认为这一发现是由于胞饮作用造成的。Parsons和Wingate在离体肠段中也证明了“上行”水运输（7）。为了对在某些组织中观察到的溶质和水运动之间的显著耦合找到物理解释，Curran（8）提出并与McIntosh和Ogilvie成功测试了（9，10）一个由串联排列的两个膜组成的模型，该模型可以解释水的明显“上坡”运输。Patlak、Goldstein和霍夫曼（11）最近发表了对柯伦模型的详细数学处理，他们能够从该模型中预测出这样一个系统的许多意想不到的特性。
Recent studies of the isolated fish gallbladder by Diamond (2-4) showed that active, electrically neutral transport of sodium chloride provides the driving force for the absorption of water from the gallbladder lumen. The extent to which water absorption is coupled to active solute transport was indicated by the demonstration of net water absorption against significant osmotic gradients across the gallbladder wall. Similar findings were reported in studies of the isolated rabbit gallbladder (5) in which it was also demonstrated that bicarbonate participates in active solute transport. Transport of water against osmotic gradients was demonstrated in the canine gallbladder inl vivo by Grim (6), who suggested that the findings were due to pinocytosis. "Uphill" water transport was also demonstrated in isolated intestinal segments by Parsons and Wingate (7). In an effort to find a physical explanation for the remarkable coupling between solute and water movement observed in certain tissues, Curran (8) proposed and with McIntosh and Ogilvie successfully tested (9, 10) a model consisting of two membranes arranged in series, which could account for apparent "uphill" transport of water. Patlak, Goldstein, and Hoffman (11) recently published a detailed mathematical treatment of the Curran model from which they were able to predict a number of unexpected characteristics of such a system.