Integrin-linked kinase and associated proteins (review).
Integrin-linked kinase and associated proteins (review).
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DOI：
10.3892/ijmm.3.6.563
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发表时间：
1999-06
影响因子：
5.4
通讯作者：
Y. Huang;C. Wu
中科院分区：
文献类型：
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作者：
Y. Huang;C. Wu
整合素连接激酶（ILK）是最近发现的一种细胞质蛋白丝氨酸/苏氨酸激酶，参与整合素、生长因子和Wnt信号通路。它包含几个结构保守的基序，包括锚蛋白重复序列，pleckstrin-homology（PH）结构域和蛋白激酶催化结构域，这些结构域对信号转导至关重要。最近的研究表明，ILK通过整合素和其他蛋白质在双向（和）跨膜信号传导途径中起重要作用，导致调节细胞粘附、生长、存活、细胞外基质沉积和潜在分化。此外，ILK与肿瘤发生有关，ILK似乎是某些人类肿瘤的有用诊断标志物。新的ILK相关蛋白的鉴定将提供一个更好地了解ILK如何在细胞内信号转导级联和肿瘤发生的功能。
Integrin-linked kinase (ILK) is a recently identified cytoplasmic protein serine/threonine kinase implicated in integrin-, growth factor- and Wnt-signaling pathways. It contains several structurally conserved motifs including ankyrin repeats, pleckstrin-homology (PH) domain and protein kinase catalytic domain that are critical for signal transduction. Recent studies have documented that ILK plays important roles in bi-directional ( and ) transmembrane signaling pathways via integrins and other proteins, leading to regulation of cell adhesion, growth, survival, extracellular matrix deposition and potentially differentiation. Furthermore, ILK is implicated in tumorigenesis and ILK appears to be a useful diagnostic marker of certain human tumors. The identification of novel ILK-associated proteins will provide a better understanding of how ILK functions in intracellular signal transduction cascades and tumorigenesis.