The role of cholesteryl ester hydrolysis and synthesis in cholesterol transport across rat intestinal mucosal membrane: a new concept.
The role of cholesteryl ester hydrolysis and synthesis in cholesterol transport across rat intestinal mucosal membrane: a new concept.
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胆固醇酯水解和合成在胆固醇跨大鼠肠粘膜转运中的作用：一个新概念。
DOI：
10.1016/0006-291x(82)91747-8
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发表时间：
1982
影响因子：
3.1
通讯作者：
Brockman,HL
中科院分区：
文献类型：
--
作者：
Bhat,SG;Brockman,HL
胆固醇酯在大鼠肠囊中的蓄积速率通过向摄取介质中加入猪胆固醇酯酶而提高达3倍。为此，酶必须具有催化活性，并且不通过其在培养基中的活性发挥其作用。这种速率提高的机制，提出了胆固醇酯酶的作用在双层膜的两侧可以催化胆固醇的净跨膜运动。
The rate of accumulation of cholesteryl ester in rat intestinal sacs is enhanced up to 3-fold by the addition of porcine cholesterol esterase to the uptake medium. For this the enzyme must be catalytically active and does not exert its effect via its activity in the medium. A mechanism for this rate enhancement is proposed in which the action of cholesterol esterases on both sides of a bilayer membrane can catalyze the net transmembrane movement of cholesterol.