Harnessing nanobodies to expand the recognition spectrum of plant NLRs for diverse pathogens
Harnessing nanobodies to expand the recognition spectrum of plant NLRs for diverse pathogens
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DOI：
10.1007/s42994-023-00111-x
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Yuese Ning
中科院分区：
文献类型：
--
作者：
Ruyi Wang;Guo-Liang Wang;Yuese Ning
The strategy to expand the recognition spectrum of plant nucleotide-binding domain leucine-rich.repeat (NLR) proteins by modifying their recognition sequences is generally limited and often.unsuccessful. Kourelis et al. introduced a groundbreaking approach for generating a customized.immune receptor, called Pikobody. This method involves integrating a nanobody domain of a fluorescent protein (FP) into a plant NLR. Their research demonstrates that the resulting Pikobody successfully initiates an immune response against diverse pathogens when exposed to the corresponding FP
