Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine
Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine
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DOI：
10.1016/j.vaccine.2007.07.051
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发表时间：
2007-10-10
期刊：
影响因子：
5.5
通讯作者：
Weinberg, Adriana
中科院分区：
文献类型：
--
作者：
Patterson-Bartlett, Julie;Levin, Myron J.;Weinberg, Adriana
为了确定老年人对带状疱疹疫苗的T细胞应答的表型特征和动力学，20名年龄≥ 60岁的受试者间隔6周接受两剂疫苗或安慰剂。VZV特异性T细胞表型和细胞内细胞因子通过流式细胞术测定接种前和第二次免疫后6个月获得的血液单核细胞。结果与5名未接种疫苗的年轻人的反应进行了比较。接种前，与年轻人相比，老年人的VZV特异性效应子和产生精氨酸的T细胞显著降低。疫苗显著增加VZV特异性Th1、记忆、早期效应和皮肤归巢受体携带T细胞。(c)2007爱思唯尔有限公司保留所有权利。
To define the phenotypic characteristics and kinetics of T cell responses to a shingles vaccine in elderly individuals, 20 subjects >= 60 years of age received two doses of vaccine or placebo 6 weeks apart. VZV-specific T cell phenotypes and intracellular cytokines were determined by flow cytometry on blood mononuclear cells obtained pre-vaccination and up to 6 months after the second immunization. Results were compared with responses of five unvaccinated young adults. Pre-vaccination, elderly individuals had significantly lower VZV-specific effectors and cytokine-producing T cells compared with young adults. The vaccine significantly increased VZV-specific Th1, memory, early effector, and cutaneous homing receptor-bearing T cells. (c) 2007 Elsevier Ltd. All rights reserved.