Cancer stem cells in glioma: challenges and opportunities.
Cancer stem cells in glioma: challenges and opportunities.
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DOI：
10.3978/j.issn.2218-676x.2013.08.01
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发表时间：
2013-10-01
影响因子：
0.9
通讯作者：
Cooper MK
中科院分区：
文献类型：
--
作者：
Wang J;Ma Y;Cooper MK
神经胶质瘤中癌症干细胞的发现为我们对这种致命疾病的理解带来了范式转变。神经胶质瘤干细胞表现出持续的自我更新和强大的致瘤潜力，并且在对当前治疗的反应中不同于其更分化的后代。复发性疾病可能源自胶质瘤干细胞或重新编程以获得干细胞样表型的后代，这表明干细胞表型是一个重要的治疗靶点。虽然关于癌症干细胞和克隆进化模型的争论仍在继续，但在过去十年中，从胶质瘤干细胞研究中获得了重要的知识，并预计会产生临床影响。
The discovery of cancer stem cells in glioma has created a paradigm shift in our understanding of this deadly disease. Glioma stem cells exhibit sustained self-renewal and potent tumorigenic potential and differ from their more differentiated progeny in response to current therapies. Recurrent disease is likely derived from glioma stem cells or progeny reprogrammed to gain stem cell-like phenotypes, indicating that the stem cell phenotype is a crucial therapeutic target. While debate over cancer stem cell and clonal evolution models persists, important knowledge has been gained over the past decade from glioma stem cells investigation and clinical impact is expected.