Apoptosis and ovarian function.
Apoptosis and ovarian function.
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DOI：
10.1530/ror.0.0010162
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发表时间：
1996-09
期刊：
影响因子：
--
通讯作者：
J. Tilly
中科院分区：
文献类型：
--
作者：
J. Tilly
几十年来，无论是在围产期直接还是在出生后通过卵泡闭锁间接导致卵巢生殖细胞枯竭，其机制仍然相对不明。最近应用敏感的生化技术研究细胞死亡来分析卵巢功能表明，这两个事件以及卵巢细胞变性(黄体溶解)的第三个实例依赖于生理细胞死亡机制的激活。因此，假设卵巢细胞群体的受控删除是通过激活细胞自杀的“普遍”途径来完成的，该途径涉及一组保守基因的表达改变。本文就卵巢细胞在发育过程中负责协调生死决策的激素效应因子和细胞内效应因子的特性以及卵巢中基因导向的细胞死亡的生物学和临床意义进行了探讨。
For decades, the mechanisms responsible for germ cell depletion from the ovary, either directly during the perinatal period or indirectly via follicular atresia during postnatal life, have remained relatively obscure. The recent application of sensitive biochemical techniques for the study of cell death to the analysis of ovarian function has revealed that these two events, as well as a third instance of ovarian cell degeneration (luteolysis), are dependent upon the activation of physiological cell death mechanisms. It is therefore hypothesized that the controlled deletion of ovarian cell populations is accomplished via activation of a 'universal' pathway of cellular suicide involving altered expression of a conserved cohort of genes. The identity of the hormonal and intracellular effectors responsible for the coordination of life and death decisions made by ovarian cells during development as well as the biological and clinical implications of gene-directed cell death in the ovary are explored in this review.