Substance P, like acetylcholine, augments one type of Ca2+ current in isolated smooth muscle cells.
Substance P, like acetylcholine, augments one type of Ca2+ current in isolated smooth muscle cells.
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P 物质与乙酰胆碱一样，可增强分离的平滑肌细胞中的一种 Ca2 电流。
DOI：
10.1007/bf00594191
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
WalshJr,JV
中科院分区：
文献类型：
--
作者：
Clapp,LH;Vivaudou,MB;Singer,JJ;WalshJr,JV
电生理记录显示，P物质可增强两种钙电流中的一种。也就是说，P物质增强了缓慢失活的高阈值电流，但不增强快速失活的低阈值电流。乙酰胆碱具有相同的作用，但乙酰胆碱的作用被阿托品阻断，而P物质的作用不被阻断，这表明两种药物作用于不同的受体位置。因此，像乙酰胆碱一样，P物质对这些研究中使用的平滑肌细胞具有双重兴奋作用，如这里所证明的那样，增强特定类型的钙电流，并如前所述抑制电压敏感型K+电导[Sims，S.M.，Walsh，J.V.，Jr.]。&Singer，J.J.(1986)AmJ.Physiol.251，C580-C587]。
Electrophysiological recordings from freshly-dissociated smooth muscle cells from toad stomach revealed that substance P enhances one of two types of Ca2+currents. That is, substance P enhances the slowly inactivating, high-threshold current but not the fast inactivating, low-threshold current. Acetylcholine has the same effect, but the acetylcholine action is blocked by atropine whereas the substance P action is not, indicating that the two agents act at different receptor sites. Thus substance P, like acetylcholine, has a dual excitatory action on the smooth muscle cells employed in these studies, enhancing a specific type of Ca2+current, as demonstrated here, and suppressing a voltage-sensitive K+conductance as previously described [Sims, S.M., Walsh, J.V., Jr. & Singer, J.J. (1986) Am. J. Physiol.251, C580–C587].