Macrophages in the Inflammatory Phase following Myocardial Infarction: Role of Exogenous Ubiquitin.
Macrophages in the Inflammatory Phase following Myocardial Infarction: Role of Exogenous Ubiquitin.
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心脏病是全世界死亡的主要原因。心脏病的一个常见症状是心肌梗塞，通常称为心脏病发作。一般来说，当心脏某部分的血液供应因脂肪堆积而减少或阻塞时，就会发生心肌梗塞。这种血流阻塞会损害部分心肌并降低心脏功能。为了补偿这种损伤，心脏开始重塑，其中包括炎症、增殖和成熟三个重叠阶段。本综述重点关注炎症阶段，特别是巨噬细胞和泛素在心肌梗死后心脏修复中的作用，并讨论泛素如何影响巨噬细胞功能。巨噬细胞是一种特殊的血细胞，在伤口愈合中发挥着关键作用。泛素是血浆中发现的一种高度进化保守的蛋白质。在包括心脏病在内的多种疾病状态下，血浆泛素水平会升高。心血管疾病（CVD）是全世界导致死亡的主要原因之一。 CVD 最常见的影响之一是心肌梗塞 (MI)。心肌梗死后，梗塞心脏的修复通过三个不同但重叠的阶段进行：炎症、增殖和成熟。巨噬细胞由于其在吞噬作用和胞吞作用中的作用，对于炎症阶段的消退至关重要。然而，损伤区域巨噬细胞长期过度积累和功能失调可能会导致心肌梗死后发生不良的心脏重塑。泛素 (UB) 是一种高度进化保守的小蛋白，是血浆的正常成分。在多种病理状况下，包括缺血性心脏病，血浆中的尿素水平会增加。 UB 小鼠的治疗与缺血/再灌注损伤后炎症反应的减少和心脏功能的改善有关。本文总结了巨噬细胞在心肌梗死后心脏梗死愈合过程中的作用，并讨论了外源性UB在心肌梗死后心肌重塑以及巨噬细胞表型和功能调节中的作用。
Heart disease is a major cause of death worldwide. A common implication of heart disease is myocardial infarction, commonly known as heart attack. Generally, myocardial infarction happens when the blood supply to a portion of the heart is reduced or blocked due to fat buildup. This blockage of blood flow damages part of the heart muscle and decreases heart function. To compensate for this injury, the heart initiates remodeling which consists of three overlapping phases of inflammation, proliferation, and maturation. This review focusses on the inflammatory phase, specifically the roles of macrophages and ubiquitin in heart repair following myocardial infarction, and discusses how ubiquitin could impact macrophage function. Macrophages are specialized blood cells with a critical role in wound healing. Ubiquitin is a highly evolutionarily conserved protein found in plasma. Plasma ubiquitin levels are increased in several disease states, including heart disease. Cardiovascular disease (CVD) is one of the leading causes of death worldwide. One of the most common implications of CVD is myocardial infarction (MI). Following MI, the repair of the infarcted heart occurs through three distinct, yet overlapping phases of inflammation, proliferation, and maturation. Macrophages are essential to the resolution of the inflammatory phase due to their role in phagocytosis and efferocytosis. However, excessive and long-term macrophage accumulation at the area of injury and dysregulated function can induce adverse cardiac remodeling post-MI. Ubiquitin (UB) is a highly evolutionarily conserved small protein and is a normal constituent of plasma. Levels of UB are increased in the plasma during a variety of pathological conditions, including ischemic heart disease. Treatment of mice with UB associates with decreased inflammatory response and improved heart function following ischemia/reperfusion injury. This review summarizes the role of macrophages in the infarct healing process of the heart post-MI, and discusses the role of exogenous UB in myocardial remodeling post-MI and in the modulation of macrophage phenotype and function.
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影响因子：
15.9
作者：
Glinton, Kristofor E.;Ma, Wanshu;Lantz, Connor;Grigoryeva, Lubov S.;DeBerge, Matthew;Liu, Xiaolei;Febbraio, Maria;Kahn, Mark;Oliver, Guillermo;Thorp, Edward B.
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Thorp, Edward B.
影响因子：
10.8
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de Lucia C;Grisanti LA;Borghetti G;Piedepalumbo M;Ibetti J;Lucchese AM;Barr EW;Roy R;Okyere AD;Murphy HC;Gao E;Rengo G;Houser SR;Tilley DG;Koch WJ
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Koch WJ
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影响因子：
0.9
作者：
Cai J;Qian X;Qi Q;Han J;Zhu X;Zhang Q;Xia R
通讯作者：
Xia R
影响因子：
15.9
作者：
Fadok, VA;Bratton, DL;Henson, PM
通讯作者：
Henson, PM
影响因子：
30.5
作者：
Dick, Sarah A.;Macklin, Jillian A.;Epelman, Slava
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Epelman, Slava