Isolation of Sesquiterpene-Amino Acid Conjugates, Onopornoids A-D, and a Flavonoid Glucoside from Onopordum alexandrinum
Isolation of Sesquiterpene-Amino Acid Conjugates, Onopornoids A-D, and a Flavonoid Glucoside from Onopordum alexandrinum
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DOI：
10.1021/acs.jnatprod.8b00948
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发表时间：
2019-06-01
影响因子：
5.1
通讯作者：
Matsunami, Katsuyoshi
中科院分区：
文献类型：
--
作者：
Sugimoto, Sachiko;Yamano, Yoshi;Matsunami, Katsuyoshi
以前的植物化学研究已经揭示了各种化合物的存在，如吡咯烷衍生物，黄酮类化合物，和megastigmanes在埃及植物。Onopordum alexandrinum传统上被当地人用于治疗皮肤癌和麻风病。本文报道了四种新的倍半萜氨基酸共轭物，即单体A ~ D（1-4），从该植物地上部分分离得到3个榄香烷和1个大根香叶烷，沿着一个新的酰化黄酮苷（5）和9个已知化合物（6-14）。基于化学和光谱/光谱数据解析结构。
Previous phytochemical investigations have revealed the presence of a variety of compounds such as pyrrolidine derivatives, flavonoids, and megastigmanes in Egyptian plants. Onopordum alexandrinum has been traditionally used by the natives for treatment of skin cancers and leprosy. In this paper the isolation of four new sesquiterpene amino acid conjugates, onopornoids A-D (1-4), i.e., three elemanes and one germacrane, and a new acylated flavonoid glucoside (5) along with nine known compounds (6-14) from the whole aerial parts of the title plant is discussed. The structures were elucidated based on chemical and spectroscopic/spectrometric data.