The relationship of I-131 6 beta-iodomethyl-19-norcholesterol (NP-59) adrenal cortical uptake to indices of androgen secretion in women with hyperandrogenism.
The relationship of I-131 6 beta-iodomethyl-19-norcholesterol (NP-59) adrenal cortical uptake to indices of androgen secretion in women with hyperandrogenism.
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I-131 6 β-碘甲基-19-去甲胆固醇 (NP-59) 肾上腺皮质摄取与高雄激素血症女性雄激素分泌指数的关系。
DOI：
10.1097/00003072-198405000-00005
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发表时间：
1984
影响因子：
10.6
通讯作者：
Beierwaltes,WH
中科院分区：
文献类型：
--
作者：
Gross,MD;Shapiro,B;Freitas,JE;Ayers,J;Swanson,DP;Woodbury,MC;Schteingart,DE;Beierwaltes,WH
地塞米松抑制 (DS) 肾上腺皮质闪烁扫描已被证明可用于检测雄激素过多症女性的肾上腺病理。然而，肾上腺皮质摄取1-131 6 β-碘甲基降胆固醇(NP-59)与肾上腺雄激素分泌水平之间的关系尚未确定。对 39 名患有多毛症和雄激素过多症的女性进行了 DS 肾上腺闪烁扫描的回顾性分析。在 14 名具有正常成像模式的患者中，使用半操作员独立计算机算法计算的体内肾上腺碘胆固醇摄取量与尿 17-酮类固醇 (17-KS) 的排泄量不相关。相反，在 20 名表现出异常双侧早期影像模式的患者中，肾上腺 NP-59 摄取与尿 17-KS 排泄水平显着相关（r = 0.65，P < 0.05）。迄今为止，这 20 名患者中的 7 名已经接受了确认程序，记录了肾上腺作为雄激素分泌的贡献部位。由于雄激素分泌性肾上腺皮质腺瘤，其他 5 名具有单侧成像模式的患者也发现与尿 17-KS 排泄具有类似的相关性（r = 0.94，P < 0.005）。在任何组中均未观察到肾上腺 NP-59 摄取与血浆睾酮或硫酸脱氢表雄酮水平之间的相关性。因此，DS 下肾上腺对 NP-59 的摄取反映了雄激素过多女性雄激素分泌的量度。
Dexamethasone suppression (DS) adrenal cortical scintigraphy has been shown to be useful in the detection of the adrenal pathology in women with hyperandrogenism. However, a relationship between adrenal cortical uptake of 1-131 6 [beta]-iodomethylnorcholesterol (NP-59) and the level of adrenal androgen secretion has not been established. A retrospective analysis of DS adrenal scintiscans has been performed on 39 women with hirsutism and hyperandrogenism. In 14 patients with normal patterns of imaging, in vivo adrenal gland iodocholesterol uptake, calculated using a semioperator-independent-computer algorithm, did not correlate with the excretion of urinary 17-ketosteroids (17-KS). In contrast, in 20 patients demonstrating abnormal bilateral early imaging patterns, adrenal gland NP-59 uptake correlated significantly with the level of urinary 17-KS excretion (r= 0.65, P< 0.05). To date seven of these 20 patients have had confirmatory procedures documenting the adrenal glands as contributing sites of androgen secretion. A similar correlation with urinary 17-KS excretion was seen in five other patients with unilateral imaging patterns (r= 0.94, P< 0.005), due to androgen-secreting adrenal cortical adenomas. No correlation between adrenal NP-59 uptake and plasma testosterone or dehydroepiandrosterone sulphate levels was observed in any of the groups. Thus, adrenal gland uptake of NP-59 under DS reflects a measure of androgen secretion in women with androgen excess.