THE ORGANIZATION OF MIDBRAIN PROJECTIONS TO THE VENTRAL STRIATUM IN THE PRIMATE
THE ORGANIZATION OF MIDBRAIN PROJECTIONS TO THE VENTRAL STRIATUM IN THE PRIMATE
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DOI：
10.1016/0306-4522(94)90181-3
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发表时间：
1994-04-01
期刊：
影响因子：
3.3
通讯作者：
HABER, SN
中科院分区：
文献类型：
--
作者：
LYNDBALTA, E;HABER, SN
由于中脑的多巴胺能神经元形成一个连续体，因此在灵长类动物中，腹侧被盖区、黑质部和红核后区之间的边界很难区分。因此，多巴胺能神经元被细分为更容易辨别的背侧和腹侧层。从这些背侧和腹侧层神经元的腹侧中脑腹侧纹状体的预测标记注射辣根过氧化物酶共轭小麦胚芽凝集素和荧光黄共轭葡聚糖胺到不同地区的核腹侧尾状核，和喙，腹侧壳核的灵长类动物。投射到腹侧纹状体的神经元在腹侧中脑中没有拓扑学组织。逆行标记的神经元被发现在腹侧层的内侧致密细胞区注射到腹侧纹状体的空气区域后，除了腹内侧壳核区域。这些内侧黑质神经元在腹侧纹状体的整个中外侧范围内具有分叉的投射。此外，背侧层的神经元项目的所有腹侧纹状体区域检查。值得注意的是，神经元投射到壳区的脑桥核仅限于背层，整个吻尾侧范围的黑质。背和腹层神经元支配腹侧纹状体。腹侧被盖区的神经元不仅投射到腹侧纹状体，而且投射到腹侧纹状体的神经元也很多。投射到壳区域的核腹侧纹状体受到更多的限制，这表明该腹侧纹状体亚区的多巴胺能调节与腹侧纹状体的其他部分不同。
Because the dopaminergic neurons of the midbrain form a continuum, boundaries between the ventral tegmental area, substantia nigra pars compacta, and retrorubral area are difficult to distinguish in the primate. Therefore, dopaminergic neurons have been subdivided into more readily discernible dorsal and ventral tiers. The projections from these dorsal and ventral tier neurons of the ventral mesencephalon to the ventral striatum were labeled by injections of horseradish peroxidase conjugated to wheatgerm agglutinin and Lucifer Yellow conjugated to dextran amines into different regions of the nucleus accumbens, the ventral caudate nucleus, and the rostral, ventral putamen in the primate. Neurons projecting to the ventral striatum are not topographically organized in the ventral mesencephalon. Retrogradely labeled neurons are found in the medial densocellular zone of the ventral tier following injections into air regions of the ventral striatum except the ventromedial shell region of the nucleus accumbens. These medial nigral neurons have diverging projections throughout the mediolateral extent of the ventral striatum. In addition, neurons of the dorsal tier project to all ventral striatal regions examined. Notably, neurons projecting to the shell region of the nucleus accumbens are limited to the dorsal tier, throughout the rostrocaudal extent of the substantia nigra.Both dorsal and ventral tier neurons innervate the ventral striatum. Not only do neurons of the ventral tegmental area project to the ventral striatum, but also many of the pars compacta. The projections to the shell region of the nucleus accumbens are more restricted, suggesting that the dopaminergic regulation of this accumbens subterritory is distinct from the rest of the ventral striatum.