Acne phototherapy with a high-intensity, enhanced, narrow-band, blue light source: an open study and in vitro investigation
Acne phototherapy with a high-intensity, enhanced, narrow-band, blue light source: an open study and in vitro investigation
复制标题
DOI：
10.1016/s0923-1811(02)00068-3
复制
发表时间：
2002-11-01
影响因子：
4.6
通讯作者：
Tezuka, T
中科院分区：
文献类型：
--
作者：
Kawada, A;Aragane, Y;Tezuka, T
本研究的目的是探讨新开发的高强度、增强、窄带蓝光光源对轻至中度痤疮患者的光疗效果。在痤疮患者中进行了一项开放研究，这些患者每周治疗两次，持续5周。痤疮病变减少了64%。两名患者感到干燥。没有患者因不良反应而停止治疗。体外研究表明，该光源照射可减少痤疮患者体内分离的痤疮丙酸杆菌（P. acnes）的数量，但对表皮葡萄球菌（Staphylococcus epidermidis）没有影响。使用该蓝光光源的光疗在痤疮患者中有效且耐受性良好，并且能够减少体外痤疮P.痤疮的数量，表明该光疗可能是治疗痤疮的一种新方式。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate acne. An open study was performed in acne patients who were treated twice a week up to 5 weeks. Acne lesions were reduced by 64%. Two patients experienced dryness. No patient discontinued treatment due to adverse effects. In vitro investigation revealed that irradiation from this light source reduced the number of Propionibacterium acnes (P. acnes), but not Staphylococcus epidermidis that were isolated from the acne patients. Phototherapy using this blue light source was effective and well tolerated in acne patients and had an ability to decrease numbers of P. acnes in vitro, suggesting that this phototherapy may be a new modality for the treatment of acne. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.