Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome
Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome
复制标题
DOI：
10.1038/sj.ijo.0802609
复制
发表时间：
2004-05-01
影响因子：
4.9
通讯作者：
Levy, Y
中科院分区：
文献类型：
--
作者：
Aronson, D;Bartha, P;Levy, Y
目的：目的：探讨C反应蛋白（CRP）与代谢综合征各特征的关系，设计：以人群为基础的横断面研究，对象：在预防医学门诊接受体检的1929名受试者（年龄，50+/-10岁; 63%男性）。CRP水平高于临界点的受试者比例通常用于指示明显的感染或炎症来源在正常体重、超重和肥胖的受试者中，（> 10 mg/l）分别为3%、7%和15%。无论是否患有代谢综合征，肥胖患者的CRP水平均显著高于非肥胖患者。然而，无代谢综合征的非肥胖受试者与根据肥胖以外的标准诊断为代谢综合征的受试者之间的CRP水平无显著差异（校正的几何平均CRP 1.75 vs 2.08 mg/l，P = 0.79）。同样，CRP水平在有和没有代谢综合征的肥胖受试者之间没有差异（校正的几何平均CRP 3.22 vs 3.49 mg/l，P = 0.99）。CRP水平随着代谢紊乱数量的增加而线性增加（P趋势< 0.0001），在控制体重指数（BMI）后显著减少（P趋势= 0.1）。逐步多元线性回归分析确定BMI、甘油三酯水平、HDL胆固醇水平（反向）和空腹血糖与CRP水平独立相关。然而，BMI占CRP水平变异的15%，而甘油三酯，HDL胆固醇和空腹血糖水平仅占CRP水平变异的1%。结论：肥胖是代谢综合征患者CRP升高的主要相关因素。CRP水平在表明感染或炎症来源的范围内（>10 mg/l）在肥胖受试者中比在非肥胖受试者中更常见。
OBJECTIVE: To investigate the relationship between C-reactive protein (CRP) and various characteristics of the metabolic syndrome.DESIGN: Population-based cross- sectional study.SUBJECTS: A total of 1929 subjects undergoing a medical examination in a preventive medicine clinic (age, 50+/-10 y; 63% males).RESULTS: The proportion of subjects with CRP levels above the cut point generally used to indicate an obvious source of infection or inflammation (> 10 mg/l) was 3, 7, and 15% in subjects who were normal weight, overweight, and obese, respectively. Subjects with obesity had markedly higher CRP level compared to patients without obesity regardless of whether they had the metabolic syndrome. However, there was no significant difference in CRP levels between nonobese subjects without the metabolic syndrome and subjects in whom the diagnosis of the metabolic syndrome was based on criteria other than obesity (adjusted geometric mean CRP 1.75 vs 2.08 mg/l, P = 0.79). Similarly, CRP levels did not differ among obese subjects with and without the metabolic syndrome (adjusted geometric mean CRP 3.22 vs 3.49 mg/l, P = 0.99). There was a linear increase in CRP levels with an increase in the number of metabolic disorders (P-trend < 0.0001), which was substantially diminished after controlling for body mass index (BMI) (P-trend = 0.1). Stepwise multivariate linear regression analysis identified BMI, triglyceride levels, HDL cholesterol levels (inversely), and fasting glucose as independently related to CRP levels. However, BMI accounted for 15% of the variability in CRP levels, whereas triglycerides, HDL cholesterol and fasting glucose levels accounted for only similar to1% of the variability in CRP levels.CONCLUSION: Obesity is the major factor associated with elevated CRP in individuals with the metabolic syndrome. CRP levels in the range suggesting a source of infection or inflammation (>10 mg/l) are more common among obese subjects than in nonobese subjects.