Noninvasive CT determination of arterial blood concentration of meglumine iothalamate.
Noninvasive CT determination of arterial blood concentration of meglumine iothalamate.
复制标题
无创CT测定碘酞酸葡胺的动脉血浓度。
DOI：
10.1097/00004728-199301000-00020
复制
发表时间：
1993
影响因子：
1.3
通讯作者：
Groothuis,DR
中科院分区：
文献类型：
--
作者：
Lapin,GD;Munson,RJ;Groothuis,DR
在生理成像研究中经常必须确定的量是示踪剂随时间的血液浓度。这通常通过直接动脉或静脉血液采样进行。我们研究了动脉血中的碘酞酸葡胺浓度与从一系列CT图像中包含大血管的体素确定的值之间的关系。在基于单个静脉血样本对体积平均值进行校正后，两条血液曲线之间具有极好的相关性。曲线之间的差异被证明是无关紧要的跨毛细血管运输测定的模拟。因此，我们得出结论，确定血浆浓度的CT图像是一个可靠的技术，CT跨毛细血管运输的研究。
A quantity that often must be determined in physiological imaging studies is the blood concentration of the tracer over time. This is usually performed by direct arterial or venous blood sampling. We studied the relationship between the concentration of meglumine iothalamate in arterial blood and values determined from voxels containing large blood vessels in a series of CT images at the same location over time. After correction for volume averaging based on a single venous blood sample, there was an excellent correlation between the two blood curves. Differences between the curves were shown to be inconsequential by a simulation of transcapillary transport determinations. We thus conclude that determination of plasma concentration from CT images is a reliable technique for CT transcapillary transport studies.