Cognitive-behavioral stress management buffers decreases in dehydroepiandrosterone sulfate (DHEA-S) and increases in the cortisol/DHEA-S ratio and reduces mood disturbance and perceived stress among HIV-seropositive men
Cognitive-behavioral stress management buffers decreases in dehydroepiandrosterone sulfate (DHEA-S) and increases in the cortisol/DHEA-S ratio and reduces mood disturbance and perceived stress among HIV-seropositive men
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DOI：
10.1016/s0306-4530(99)00010-4
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发表时间：
1999-07-01
影响因子：
3.7
通讯作者：
Schneider, N
中科院分区：
文献类型：
--
作者：
Cruess, DG;Antoni, MH;Schneider, N
本研究检测了为期10周的认知行为压力管理（CBSM）干预对脱氢表雄酮硫酸盐（DHEA-S）水平和皮质醇与DHEA-S的比值（皮质醇/DHEA-S）的影响，DHEA-S是HIV疾病进展的潜在替代肾上腺标志物，与情绪和痛苦的改变有关。hiv血清阳性的男性被随机分配到以小组为基础的CBSM干预组（n = 43）或等候名单对照组（n = 24），在10周之前和之后立即评估激素和痛苦测量。结果表明，CBSM缓冲DHEA-S降低，皮质醇/DHEA-S比值升高。进一步的研究还显示，皮质醇/DHEA-S比值的变化与总情绪障碍和感知压力的变化呈显著正相关。这些发现表明，在有症状的hiv阳性男性中，短期CBSM干预可以缓冲DHEA-S的下降和皮质醇/DHEA-S比值的增加，并且皮质醇/DHEA-S比值的变化与CBSM期间观察到的情绪和痛苦的变化一致。1999爱思唯尔科学有限公司版权所有。
This study examined the effects of a 10-week cognitive-behavioral stress management (CBSM) intervention on dehydroepiandrosterone sulfate (DHEA-S) levels and the ratio of cortisol to DHEA-S (cortisol/DHEA-S), potential surrogate adrenal markers of HIV disease progression, in relation to alterations in mood and distress. HIV-seropositive men were randomized to either a group-based CBSM intervention (n = 43) or to a wait-list control group (n = 24), with both hormonal and distress measures assessed just prior to and immediately following the 10-week period. Results showed that CBSM buffers decreases in DHEA-S and increases in the cortisol/DHEA-S ratio. Further examination also revealed that changes in the cortisol/DHEA-S ratio were significantly and positively related to changes in total mood disturbance and perceived stress over time. These findings demonstrate that a short-term CBSM intervention can buffer against decrements in DHEA-S and increments in the cortisol/DHEA-S ratio among symptomatic, HIV-positive men, and that alterations in the cortisol/DHEA-S ratio move in concert with changes in mood and distress observed during CBSM. (C) 1999 Elsevier Science Ltd. All rights reserved.