Molecular and cell biology of skeletal muscle regeneration.
Molecular and cell biology of skeletal muscle regeneration.
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DOI：
10.1007/978-94-011-1528-5_9
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
M. Grounds;Z. Yablonka-Reuveni
中科院分区：
文献类型：
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作者：
M. Grounds;Z. Yablonka-Reuveni
当骨骼肌受损时，它通过单核肌肉前体细胞(MPC)的增殖来修复，MPC彼此融合形成年轻的多核肌肉细胞(肌管)或与受损的肌纤维末端融合(Robertsonet al.，1990)。新肌肉的成功形成与损伤的大小有关，因为在严重创伤和肌肉纤维外板广泛破坏后，往往会有大量的纤维和细胞结缔组织取代。肌肉再生受损并被脂肪和结缔组织逐渐替代是Duchenne肌营养不良(DMD)等肌肉疾病的一个特征，尽管这是由于许多小的离散病变在很长一段时间内不断复发导致的，而不是单一的大损伤。失败的再生可以简单地视为肌肉前体复制的失败。在这篇综述中，我们将集中于肌肉前体细胞的生物学。有关再生的其他方面的报道，如损伤肌纤维的重新密封、血运重建和神经再支配，见GRASS(1991)。
When skeletal muscle is damaged, it is repaired by the proliferation of mononuclear muscle precursor cells (mpc) which fuse either with one another to form young multinucleated muscle cells (myotubes) or with the ends of damaged myofibres (Robertsonet al., 1990). The success of new muscle formation is related to the size of the injury, as after major trauma and extensive disruption of the external lamina of muscle fibres there is often significant replacement by fibrous and cellular connective tissue. Impaired muscle regeneration and progressive replacement by fat and connective tissue is a feature of myopathies such as Duchenne muscular dystrophy (DMD), although this results from many small discrete lesions constantly recurring over a long period of time rather than from a single large injury. Failed regeneration can be seen in simplistic terms as a failure of muscle precursor replication. In this review we shall concentrate on the biology of muscle precursor cells. For coverage of other aspects of regeneration such as resealing of damaged myofibres, revascularization and reinnervation, see Grounds (1991).